早期干预对早产儿脑损伤预后的临床观察

目的:探讨早期联合干预对脑损伤早产儿智能及运动发育的影响。方法:80例存在脑损伤的早产儿随机分为干预组与对照组,每组各40例,对照组给予常规治疗与保健指导,干预组在此基础上联合神经节苷脂治疗与早期康复训练,定期随访两年,观察比较患儿纠正胎龄40周时神经行为评分(NBNA),智力及运动发育情况。结果:干预组患儿纠正胎龄40周NBNA评分为33.04±1.12,对照组NBNA评分为30.95±0.88,两组间差异有统计学意义(P<0.05);干预组MDI与PDI指数分别于9月龄始和6月龄始显著高于对照组(P<0.01或0.05);1岁时进行Gesell智力发育检查,干预组大运动、精细动作、适应性、语言、个人-社会交往等五个能区情况均明显好于对照组(P<0.01);干预组17.5%的后遗症发生率显著低于对照组32.5%的发生率(P<0.01)。结论:联合早期干预治疗可有效促进脑损伤早产儿神经系统功能修复,改善智能及运动发育,减少后遗症发生。

Clinical Research on Early Intervention to Prognosis of Premature Infants with Brain Damage

Objective:To explore the clinical effects of early comprehensive intervention on development of intelligence and motor in preterm infants with brain injury.Methods: 80 infants with brain damage were divided into two groups,the control group(n=40) received conventional therapy and health care instruction,and the intervention group(n=40) also received early synthesis intervention(GM-1+rehabilitation training).The infants in both groups were followed up regularly for 2 years,and were examined neonatal behavior...