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| 缬沙坦联合培哚普利对慢性心力衰竭患者心功能及血浆BNP、CRP、IL-6 的影响 | |
| 引用本文： | 万荣文,邓湘辉,管燕,唐建军,邓阳春.缬沙坦联合培哚普利对慢性心力衰竭患者心功能及血浆BNP、CRP、IL-6 的影响[J].现代生物医学进展,2011,11(17):3325-3328. |
| 作者姓名： | 万荣文 邓湘辉 管燕 唐建军 邓阳春 |
| 作者单位： | 1. 长沙市中心医院重症医学科 湖南长沙410004 2. 中南大学湘雅二医院重症医学科 湖南长沙410011 3. 湖南永州市职业技术学院附属医院心内科 湖南永州425000 |
| 摘 要： | 目的:观察缬沙坦联合培哚普利对慢性心力衰竭(CHF)的治疗效果,以及对患者心功能、血浆脑利钠肽(BNP)、C反应蛋白(CRP)和IL-6的影响。方法:95例CHF患者随机分为缬沙坦治疗组(30例)、培哚普利治疗组(30例)和联合治疗组(35例),患者均予以常规西医治疗,缬沙坦治疗组或培哚普利治疗组在常规治疗基础上加用缬沙坦或培哚普利,联合治疗组则同时加用缬沙坦和培哚普利。观察治疗效果及患者心功能变化,检测治疗前后血浆BNP、CRP、IL-6的浓度。结果:联合治疗组总有效率达到91.43%,高于缬沙坦治疗组73.33%和培哚普利53.33%的总有效率(P<0.05);与缬沙坦治疗组和培哚普利治疗组相比,缬沙坦联合培哚普利可有效改善患者心功能指标,降低血浆BNP、CRP、IL-6含量。结论:缬沙坦联合培哚普利能有效改善心功能,调节细胞因子表达,优于单用缬沙坦或培哚普利治疗。 |
| 关 键 词： | 慢性心力衰竭 缬沙坦 培哚普利 心功能 血浆脑利钠肽 C反应蛋白 IL-6 |
The effect of valsartan combined with perindopril on ventricular function and plasma BNP, IL-6 and CRP in patients with CHF |
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| WAN Rong-wen,DENG Xiang-hui,GUAN Yan,TANG Jian-jun,DENG Yang-chun.The effect of valsartan combined with perindopril on ventricular function and plasma BNP, IL-6 and CRP in patients with CHF[J].Progress in Modern Biomedicine,2011,11(17):3325-3328. | |
| Authors: | WAN Rong-wen DENG Xiang-hui GUAN Yan TANG Jian-jun DENG Yang-chun |
| Institution: | WAN Rong-wen1,DENG Xiang-hui1,GUAN Yan1,TANG Jian-jun2,DENG Yang-chun3(1 Department of grave,Changsha central Hospital,Changsha 410004,China,2 Department of grave of the second Xiangya Hospita,Central South University,Changsha 410011,3 The affiliated hospital of Yongzhou vocational technical college,Yongzhou Hunan province,425000,China) |
| Abstract: | Objective:To explore the therapeutic effect of combination of valsartan and perindopril in patients with CHF,as well as ventricular function and plasma BNP,IL-6 and CRP.Methods: 95 cases with CHF were randomly divided in to valsartan-treated group(30 cases),perindopril-treated group(30 cases) and combined treatment group(35 cases).The valsartan or perindopril was added to val-sartan-treated group or perindopril-treated group on the basis of Western medicine,and valsartan combined with perindopril in combine... |
| Keywords: | chronic heart failure valsartan perindopril ventricular function BNP CRP IL-6 |
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