选择性复制型腺病毒介导的自杀基因HSV -tk 在 肿瘤基因治疗中的应用

自杀基因治疗是肿瘤基因治疗的手段之一，治疗效果与自杀基因能否被高效、选择性的导入肿瘤细胞有关。肿瘤选择性复制型腺病毒（conditionally replication adenovirus，CRADs）可以特异性的在肿瘤细胞中复制，在复制的同时所携带的治疗基因也大量表达。由CRAds介导的自杀基因，实现了对肿瘤的病毒治疗和基因治疗的结合，提高了治疗效率和使用复制型腺病毒的安全性。

The application of conditionally replication adenovirus -mediated suicide gene HSV-tk in the tumor gene therapy

Suicide gene therapy is one of the approaches of tumor gene therapy. The effect of suicide gene therapy approach is concemed with genes can be delivered efficiendy and selectly to the tumor site. Conditionally replication of adenovims in tumor tissue leads to amplification of the input dose at the tumor site, while the adenovims - mediated gene can also largely replicate. Conditionally replication adenovims that contain sueide gene combine the advantages of virotherapy and suicide gene therapy, in addition, are hnproved significandy in beth efficacy and safety.