X射线损伤修复交叉互补基因1(XRCC1)单核苷酸多态性与神经胶质瘤易感性关系的meta分析(英文)

目的:采用meta分析方法探讨X射线损伤修复交叉互补基因1(XRCC1)单核苷酸多态性与神经胶质瘤易感性的关系。方法:研究检索了PubMed、EMBASE、ISIWeb ofsciences、ScienceDirect及CNKI数据库从建库至2012年9月关于XRCC1基因多态性与神经胶质瘤相关性的相关文献。合并的OR值及其95%CI用于评估不同基因模型与神经胶质瘤风险的关联强度。采用亚组分析和meta回归分析来探索潜在的异质性来源。结果:研究最终纳入12篇Arg399Gln、8篇Arg194Trp和5篇Arg280His XRCC1位点多态性与神经胶质瘤关系文章用于meta分析。Arg399Gln位点多态性在所有基因模型下合并OR值均有显著意义;Arg194Trp位点多态性在纯合子基因模型和隐性基因模型下合并OR值具有显著意义;未发现Arg280His位点多态性与神经胶质瘤风险相关基因模型。亚组分析和meta回归分析显示Arg399Gln位点多态性的所有基因模型风险仅在亚洲人群当中具有显著意义,亚洲人群的风险显著高于白种人群。Arg194Trp对照组人群不符合Hardy-Weinberg平衡(HWE)可能高估了风险。结论:本研究结果显示XRCC1 Arg399Gln基因多态性仅为亚洲人群的神经胶质瘤风险的候选基因,Arg194Trp基因多态性的风险可能是由于对照组不符合HWE的研究所导致的。

X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Risk of Glioma: A Meta-Analysis

Objective:To investigate the X-ray repair cross-complementing 1 (XRCC1) genetic polymorphisms and risk of glioma.Methods:In September, 2012, relevant articles were searched in PubMed, EMBASE, ISI Web of Knowledge, ScienceDirect database, and CNKI . ORs and 95% CIs were used to assess the strength of the associations with different genetic models. Potential sources of heterogeneity were sought out by subgroup and meta-regression analyses.Results:12, 8, and 5 studies were found to be eligible for meta-analyses of Arg399Gln, Arg194Trp, and Arg280His, respectively. For Arg399Gln, the overall odds ratios (ORs) are significant under all genetic models. For Arg194Trp, the overall fixed effects ORs were significant under homozygote genetic model and recessive genetic model. No significant results were found for Arg280His. Stratified and meta-regression analyses revealed that significant risks were only observed in Asians under all genetic models for Arg399Gln, and Asians have significantly higher risk for glioma than Caucasians. Pooled risk for studies with HWE deviation in controls seems to overestimate the risk for Arg194Trp.Conclusion:The present study suggests that the Arg399Gln is a candidate gene for glioma only for Asians, and increased risk for Arg194Trp probably due to studies deviated fromHWE in controls.