呼吸道病毒感染与慢性阻塞性肺疾病急性加重的关系

目的:探讨呼吸道病毒与慢性阻塞性肺疾病急性加重(AECOPD)的相关性,以期能为AECOPD的诊治提供参考。方法:选取200例AECOPD患者为研究对象,检测患者肺功能,用Luminex xMAP多重分析技术平台,采集患者咽试子建立多重PCR检测技术,对鼻病毒(RHV)、呼吸道合胞病毒(RSV)、流感病毒A(INF-A)、流感病毒B(INF-B)、副流感病毒(PIV)、腺病毒(ADV)进行检测。结果:200例患者肺功能分级I级25例,II级62例,III级96例,IV级17例,其构成比分别为17.50%、31.00%、48.00%、8.50%;咽试子共检出呼吸道病毒116株,检出率为58.00%,其中RHV11株、RSV36株、INF-A37株、INF-B19株、PIV10株、ADV3株,检出率分别为5.5%、18.00%、18.50%、9.50%、5.00%、1.50%;肺功能分级I级患者病毒检出率为20.00%,II级为48.39%,III级为69.79%,IV级为82.35%,病毒检出率在不同肺功能AECOPD患者中比较差异具有统计学意义(P0.05);肺功能分级与病毒检出率直线相关分析结果显示随着肺功能分级的严重程度增加患者咽试子呼吸道病毒检出率明显呈现增高趋势,两者直接具有正相关(r=0.67,P0.05)。结论:COPD患者病情加重与病毒关系密切相关,病毒感染可能参与了COPD患者的病程进展。

The Relation between Respiratory Virus Infection and Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Objective:To investigate the relation between the respiratory viruses and chronic obstructive pulmonary diseases acute exacerbation (AECOPD), and to provide reference for the diagnosis and treatment of AECOPD.Methods:200 cases of patients with AECOPD were selected as the research object, patients'' lung function were detected, and with Luminex xMAP multiple analysis technology platform, patients throat swab collected were subjected to the multiple PCR detection. Virus, namely rhinovirus (RHV), respiratory syncytial virus (RSV), influenza virus A (INF - A), influenza virus B (INF) B, parainfluenza (PIV) and adenovirus (ADV) were detected.Results:According to pulmonary function, 200 cases of in patients consist of 25 cases of class I, 62 cases of class II, 96 cases of class III and 17 cases of class IV, the constituent ratio were 17.50%, 31.00%, 48.00%, 8.50%respectively; 116 strains of respiratory viruses were detected in the throat swabs, with a detection rate of 58.00%, including 11 seedlings of RHV, 37 INF - A, 36 RSV, 10 PIV, 19 INF - B, and 3 ADV, the detection rate were 5.5%, 18.00%, 18.50%, 9.50%, 5.00%and 1.50%respectively; The virus detection rate was 20.00% in lung function class I patients, 48.39% in class II, 69.79% in class III, and 82.35% in class IV, virus detection rate in patients with AECOPD of different lung functions presenting statistically significant difference (P<0.05); Linear correlation analysis of lung function grading and virus detection rates showed that the respiratory virus detection rates increased with the severity of lung function gradings, showing a direct positive correlation (r=0.67, P<0.05).Conclusion:Disease progression in patients with COPD is closely related to the viruses and virus infection may be involved in the progression of COPD.