康复新液联合表皮生长因子预防急性放射性肠炎的疗效研究

目的:探讨康复新液联合表皮生长因子保留灌肠对盆腔肿瘤放疗后并发急性放射性肠炎的预防作用及其机制。方法:86例盆腔恶性肿瘤行放射性治疗的患者随机分为观察组和对照组,2组患者均行外照射治疗,观察组康复新液与表皮因子联合保留灌肠,每次50 mL,每日一次,对照组不加任何预防用药。比较2组急性放射性肠炎的发生率以及发生时间,并于放射治疗10次、20次后静脉采血,酶联免疫吸附法检测血清TNF-α、IL-6、IL-8,黄嘌呤氧化酶法检测MDA、SOD的含量。结果:观察组、对照组的急性放射性肠炎发生率分别为9.31%、53.49%,组间差异有统计学意义(P0.05),且观察组出现急性放射性肠炎的时间迟于对照组。观察组放射治疗10次及20次后,MDA含量明显低于对照组,SOD含量高于对照组(P0.05)。TNF-α、IL-6、IL-8含量明显低于对照组(P0.05)。结论:康复新液联合表皮生长因子可预防急性放射性肠炎的发生,其机制可能与抗细胞炎性因子与氧自由基释放有关。

Effect of Kangfuxin Liquid Combined with Epidermal Growth Factor in the Prevention of Acute Radiation Enteritis and Serum Levels of Inflammatory Cytokines, Oxygen Free Radicals

Objective:To investigate the Kangfuxin Liquid Combined with epidermal growth factor (EGF) retention enema on preventive effect and mechanism of acute radiation enteritis of pelvic tumor after radiotherapy.Methods:86 cases of pelvic malignant tumors for radiotherapy were randomly divided into observation group and control group, with the 2 groups of patients underwent external beam radiation therapy. Patients in the observation group were treated with Kangfuxin Liquid combined with EGF by retention enema, 50ml each time and once a day, while patients in the control group without any preventive medication. Compared acute radiation enteritis incidence and time of occurrence in the groups. Tested the content of TNF- alpha, IL-6, IL-8 by ELISA and that of MDA, SOD by xanthine oxidase method respectively in radiation therapy were tested for 10 times, 20 times by drawing the venous blood serum.Results:The incidence of acute radiation enteritis in the observation group and the control group of were 9.31%, 53.49% respectively, there was significant difference between the groups (P<0.05), and the observation group with acute radiation enteritis later than that in the control group. After radiotherapy for 10 times and 20 times, the content of MDA in observation group was significantly lower than the control group, and the content of SOD was higher than the control group (P<0.05). The content of TNF- alpha, IL-6, IL-8 in observation group were significantly lower than that in the control group (P<0.05).Conclusion:Kangfuxin Liquid Combined with epidermal growth factor prevents acute radioactive enteritis, the mechanismmay be related to anti-inflammatory cytokine and oxygen free radical release.