内源性大麻素系统与神经保护浅识

内源性大麻素系统包括大麻素受体、内源性配体以及参与其合成与降解的酶类,在人体内广泛分布,参与诸多生理和病理生理过程。新近报道内源性大麻素系统在中枢神经系统的许多疾病的病理生理过程中扮演重要的角色。对内源性大麻素系统的研究,不仅能阐明一些疾病的病理生理机制,还有助于新药研发并为疾病治疗提供新的方向。本文基于现有的文献报道,就内源性大麻素系统及其在一些中枢神经疾病特别是脑缺血和帕金森病的发病机制的新进展进行综述。

Views on Endocannabinoid System and the Neuroprotection

The endocannabinoid system is a complex system composed of specific receptors, endogenous ligands and specific enzymes responsible for their synthesis and degradation. The endocannabinoid system is widely distributed in human body and participated in a variety of physiological and pathophysiological processes. The endocannabinoid system plays a key role in numerous pathophysiological mechanisms of the central nervous system. Here we present a review on advance on the endocannabinoid system and its relationship with some central nervous system diseases such as Cerebral ischemia and Parkinson''s disease. The research on this regard not only elucidates the novel pathophysiological mechanism of some diseases, but also contributes to drug discovery and new therapy of these diseases.