BNP及NT-proBNP与2型糖尿病关系的研究进展

BNP及NT-proBNP是诊断心衰的重要指标。近年来BNP及NT-proBNP与2型糖尿病关系的研究有了新的进展。我们收集近年来国内外关于2型糖尿病中BNP及NT-proBNP的相关文献并进行研究。结果显示2型糖尿病合并冠心病、高血压、糖尿病肾病患者BNP或NT-proBNP有升高趋势。单纯2型糖尿病及糖尿病视网膜病变患者以及低血糖患者BNP或NT-proBNP差异无统计学意义。高血压、年龄、性别、体重指数、肾功能及心脏结构功能改变是2型糖尿病患者BNP及NT-proBNP的影响因素。降糖药物对2型糖尿病患者BNP及NT-proBNP水平的研究尚少,糖尿病病程、FPG以及HbA1c对BNP及NT-proBNP的影响尚存在争议。BNP及NT-proBNP升高对2型糖尿病合并冠心病、高血压、糖尿病肾病患者病情评估,预后判断及诊治具有非常重要的意义。降糖药物、糖尿病病程、FPG以及HbA1c对BNP及NT-proBNP的影响需要进一步研究。

Research Progress of BNP and NT-proBNP with Type 2 Diabetes Mellitus

BNP and NT-proBNP are important indicators for the diagnosis of heart failure. In recent years, the research on the relationship between BNP and NT - proBNP and type 2 diabetes have made new progress. We have collected and made research on the literatures at home and abroad with respect to BNP and NT-proBNP in the type 2 diabetes in recent years. The results show that BNP and NT-proBNP tended to increase in type 2 diabetes patients with coronary heart disease, hypertension, or diabetic nephropathy. The patients of simplex type 2 diabetes, diabetic retinopathy, and hypoglycemia have no significant difference in BNP or NT-proBNP. Hypertension, age, gender, BMI, renal function and cardiac structure and function changes were influencing factors of BNP and NT-proBNP of type 2 diabetes patients. There are few studies on hypoglycemic drugs for type 2 diabetes patients with BNP and NT-proBNP levels. It remains controversial that the duration diabetes, FPG and HbA1c had effect on BNP and NT-proBNP levels. The rise of BNP and NT-proBNP have very important significances for condition assessment, prognosis, diagnosis and treatment of patients suffering type 2 diabetes with coronary heart disease, hypertension, diabetic nephropathy. The influences of Hypoglycemic drugs, duration of diabetes, FPG and HbA1c to BNP and NT-proBNP need further study.