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食管鳞状细胞癌中HDGF、VEGF表达与微血管形成的关系
引用本文:杨进,马水根,徐朝军,尹晓清,尹邦良.食管鳞状细胞癌中HDGF、VEGF表达与微血管形成的关系[J].现代生物医学进展,2014,14(30):5956-5959.
作者姓名:杨进  马水根  徐朝军  尹晓清  尹邦良
作者单位:湖南省中医药大学第一附属医院;中南大学湘雅医学院附属肿瘤医院;中南大学湘雅二医院
基金项目:湖南省自然科学基金项目(14JJ7060)
摘    要:目的:研究食管鳞状细胞癌中肝癌衍生生长因子(HDGF)、血管内皮生长因子(VEGF)的表达及其与微血管形成的关系。方法:通过免疫组化SABC法检测和比较68例食管鳞癌、20例切缘正常组织中HDGF、VEGF的表达和CD34标记的微血管密度(MVD),分析HDGF和VEGF表达之间的关系及其与食管鳞癌患者临床病理因素和食管癌组织MVD值的关系。结果:食管鳞癌组织中HDGF(63.2%)和VEGF(72.1%)的阳性表达率均明显高于切缘正常粘膜组织(15.0%、20.0%)(P0.05),食管鳞癌组织和切缘正常粘膜组织中的MVD值分别为35.48±5.75和13.50±2.1(P0.05)。食管鳞癌组织HDGF的阳性表达率仅与其临床分期明显相关(P0.05),而VEGF的阳性表达率与其淋巴结转移、临床分期均显著相关(P0.05),二者在食管鳞癌组织中的表达呈显著正相关(P0.05)。食管鳞癌组织中HDGF、VEGF阳性表达组MVD值均明显高于HDGF、VEGF阴性表达组(P0.05)。结论:HDGF可能通过诱导VEGF的产生,从而促进血管生成,参与食管鳞癌的发生、发展及转移。

关 键 词:食管鳞状细胞癌  肝癌衍生生长因子  血管内皮生长因子  微血管密度  免疫组化法

Relationship between the Expression of HDGF, VEGF and the Angiogenesis of Esophageal Squamous Cell Carcinoma
YANG Jin,MA Shui-gen,XU Chao-jun,YIN Xiao-qing,YIN Bang-liang.Relationship between the Expression of HDGF, VEGF and the Angiogenesis of Esophageal Squamous Cell Carcinoma[J].Progress in Modern Biomedicine,2014,14(30):5956-5959.
Authors:YANG Jin  MA Shui-gen  XU Chao-jun  YIN Xiao-qing  YIN Bang-liang
Institution:YANG Jin;MA Shui-gen;XU Zhao-jun;YIN Xiao-qing;YIN Bang-liang;The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine;The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University;The Second Xiangya Hospital of the Central South University;
Abstract:Objective:To investigate the expression of hepatoma-derived growth factor (HDGF) and vascular endothelial growth factor(VEGF) and their correlation with microangiogenesis in esophageal squamous cell carcinoma(SCC).Methods:Specimens from 68 cases of esophageal SCC tissues and 20 cases of the adjacent nomal esophageal tissues were examined by immunohistochemical technique (SABC staining). The microvessel density (MVD) of tumor was evaluated using CD34 antibody as an endothelial marker with the same technique. The relationship between the expression of HDGF and VEGF was analyzed, and their correlations with clinicopathological characteristics and MVD values in patients with esophageal squamous cell carcinoma were discussed.Results:The positive expression rates of HDGF (63.2%) and VEGF (72.1%) were significantly higher in esophageal SCC tissues than those in the adjacent nomal esophageal tissues (15.0%) and (20.0%) respectively (P<0.05), and so did the MVD which was (35.48± 5.75) in esophageal SCC and (13.50± 2.1) in the adjacent nomal esophageal tissues(P<0.05). The expression of HDGF was only correlated with the clinical stage of esophageal SCC(P<0.05). The expression of VEGF had significant correlation with the clinical stage and lymph node metastasis of esophageal SCC(P<0.05). The expression of HDGF were positively corelated with the expressions of VEGF(P<0.05). The value of MVD in cases with positive expression of HDGF and VEGF were significantly higher than those cases with negative expression of HDGF and VEGF (P<0.05).Conclusion:HDGF could promote the tumor angiogenesis through inducing the production of VEGF, which was closely related to the occurrence, development and metastasis of esophageal SCC.
Keywords:Esophageal squamous cell carcinoma  Hepatoma derived growth factor  Vascular endothelial growth factor  Microvessel density  Immunohistochemical method
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