| 体外红霉素对鼻息肉组织中eotaxin的作用 |
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| 引用本文： | 王庭阔,孙虹.体外红霉素对鼻息肉组织中eotaxin的作用[J].现代生物医学进展,2010,10(4). |
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| 作者姓名： | 王庭阔 孙虹 |
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| 作者单位： | 中南大学湘雅三医院耳鼻咽喉-头颈外科,湖南,长沙,410013 |
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| 基金项目： | 国家自然科学基金资助项目(30371531,30772402); 教育部博士点基金资助项目(20030533006); 湖南省卫生厅资助项目(B20042069) |
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| 摘 要： | 目的:观察红体外霉素对体外培养鼻息肉组织中嗜酸性粒细胞趋化因子(eotaxin)的作用。方法:从27例住院病人鼻腔中各取鼻息肉标本一份,将每一份均分4份,分对照组、红霉素组培养1d、3d后。每组各取鼻息肉标本经逆转录聚合酶链式反应(RT-PCR)与免疫组织化学染色检测eotaxin表达。结果:①红霉素组中鼻息肉的eotaxinmRNA光度值较对照组低(p<0.05);②两组鼻息肉中eotaxin蛋白灰度值比较,在培养1d后无明显差异,但培养3d后,红霉素组eotaxin蛋白灰度值较对照组低(p<0.05)。结论:体外红霉素能抑制鼻息肉中eotaxin表达,对鼻息肉的临床治疗有指导作用。
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| 关 键 词： | 红霉素 鼻息肉 嗜酸性粒细胞趋化因子 |
Effect of erythromycin on eotaxin in nasal polyps in vitro |
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| WANG Ting-kuo,SUN Hong.Effect of erythromycin on eotaxin in nasal polyps in vitro[J].Progress in Modern Biomedicine,2010,10(4). |
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| Authors: | WANG Ting-kuo SUN Hong |
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| Abstract: | Objective: To observe the effect of erythromycin on eotaxin in nasal polyps in vitro. Methods: Each of 27 hospital patients nasal polyp specimens were equally divided into four portions. One group specimens were cultured with erythromycin in RPMI1640, the other group only in RPMI1640 as contral. The specimens in two groups which were used for expriment were taken out at 1 and 3 day after culture. Eotaxin mRNA expression from the two groups above were tested by RT-PCR.Sections from the two groups above were ... |
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| Keywords: | Erythromycin Nasal polyps Eotaxin |
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