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单核苷酸多态性在医学领域的应用
引用本文:魏瑜,高媛,程江,黄瑾.单核苷酸多态性在医学领域的应用[J].现代生物医学进展,2010,10(5).
作者姓名:魏瑜  高媛  程江  黄瑾
作者单位:1. 新疆石河子大学医学院第一附属医院检验科,新疆,石河子,832002
2. 石河子大学新疆地方与民族高发病教育部重点实验室/生化教研室,新疆石河子,832002
基金项目:国家科技支撑计划项目(2009BAI28B01)
摘    要:作为第三代DNA遗传标记,单核苷酸多态性(SNP)标记已经成为基因功能研究、寻找疾病基因和基因型鉴定、药物基因组学的主要研究手段,在高危群体的发现、疾病相关基因的鉴定、药物的设计和测试以及分子生物学的基础研究等方面发挥了重要作用。近年来SNP在法医鉴定等领域也有广泛应用。

关 键 词:单核苷酸多态性  基因研究  遗传易感性  应用领域  

Application of Single Nucleotide Polymorphisms to Medical Research
WEI Yu,GAO Yuan,CHENG Jiang,HUANG Jin.Application of Single Nucleotide Polymorphisms to Medical Research[J].Progress in Modern Biomedicine,2010,10(5).
Authors:WEI Yu  GAO Yuan  CHENG Jiang  HUANG Jin
Institution:WEI Yu1,GAO Yuan1,CHENG Jiang1,HUANG Jin2 (1 The First Affiliated Hospital,Shihezi University School of Medicine,2 Xinjiang endemic , ethnic diseases Laboratory/Department of Biochemistry,Shihezi Xinjiang 832002 )
Abstract:As the third generation of DNA genetic marker,SNP (Single nucleotide polymorphisms) has been the main study methods of gene function study,searching gene of diseases and genotype identification,pharmacogenomics.It has play an important role in discovering of high risk group,identification of disease related gene,design and test of medicine and foundation research of molecular biology.In recent years,SNP has been widely used in jurisprudence investigation etc.
Keywords:SNP (Single nucleotide polymorphisms)  gene study  hereditary susceptibility  Application  
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