陕西地区人群克罗恩病发病危险因素的病例对照研究

目的:探讨陕西地区人群克罗恩病发病的危险因素.方法:采用病例对照研究,选择2009年1月～2010年12月在我院就诊的64例克罗恩病患者和64例健康对照者为研究对象,通过问卷的方式进行调查,调查内容包括饮食习惯、受教育情况、职业、家庭卫生情况、吸烟、母乳喂养、肠道疾病家族史、感染性肠病史、阑尾切除术、麻疹等内容,采用条件logistic回归分析影响陕西地区人群克罗恩病发病的危险因素.结果:64例克罗恩病患者及64例配对的健康对照者均完成问卷调查,多因素条件logistic回归分析结果显示,人均居住面积(大)(OR 0.4003,95％CI 0.1577,1.0165)、饮茶(OR 0.2597,95％CI 0.0662,1.0184)、油炸食品(OR3.1465,95％CI 1.2841,7.7101)、口服避孕药(OR 5.4500,95％CI 0.8400,35.1158)是陕西地区人群克罗恩病发病的危险因素.结论:油炸食品、服避孕药可能为陕西地区人群克罗恩病发病的危险因素,人均居住面积(大)、饮茶可能为陕西地区人群克罗恩病发病保护因素.

A Case-control Study on the Risk Factors of Crohn’s Disease in Shaanxi Population

Objective： To analyze the risk factors of Crohn＇s disease in Shanxi population.Methods： A case control study was applied on 64 cases of Crohn＇s disease admitted in our hospital from January 2009 to December 2010 and 64 cases of healthy control.A survey was employed.The questionnaire consisted of 23 items,including family history of Crohn＇s disease.smoking.milk intake.work tension.alcohol intake.history of intestinal infection.Appendectomy and use of NSAID drugs,and so on.Logistic regression analysis was used to analyze the risk factors of Crohn＇s disease in Shanxi population.Results： Multivariate logistic regression analysis indicated that fried food（OR 3.1465,95%CI 1.2841,7.7101）,oral contraceptive（OR 5.4569,95%CI 0.8480,35.1158）,per capita living space（larger）（OR 0.4003,95%CI 0.1577,1.0165）,tea drink（OR 0.2597,95%CI 0.062,1.0184） were risk factors of Crohn＇s disease in Shanxi population.Conclusion： Fried food and oral contraceptive may be risk factors in the pathogenesis of Crohn＇S disease,larger per capita living space and tea may be the protective factors for Crohn＇s disease.