两种药物性肝炎诊断评分标准的临床应用分析

目的:比较Maria药物性肝损害(1997年)诊断标准和我国常用诊断标准对药物性肝损害的效价。方法:回顾性分析我院2005年1月至2006年4月期间经肝穿病理诊断为药物性肝损害的54例病例,分别按照上述两个标准评分。评价每一标准的准确性。结果:符合Maria药物性肝损害(1997年)诊断标准的(>10分)有45例,占83%;符合我国常用诊断标准的有39例,占72%。结论:两个诊断标准符合率较高,均可做为药物性肝损害的诊断标准,但仍有部分病例不能准确诊断,需进一步完善。

Clinical Application Analysis on Two Diagnostic Criteria for Drug-induced Liver Disease

Objective:To compare the capability in predicting the prognosis of Drug-induced liver injury among two pre- dicting systems:Maria Diagnostic criteria for drug-induced liver injury and China commonly used diagnostic criteria.Method:A retrospective analysis was performed on 54 consecutive patients with drug-induced liver injury by needle biopsy of liver between Janusry 2005 and April 2006.Each case was analyzed,in accordance with the above two scores,to evaluate the accuracy of each standard.Results:45 cases meet the diagnostic criteria of a drug-induced liver injury,accounting for 83%,whereas 39 cases were in line with our common diagnostic criteria,accounting for 72%.Conclusion:Two diagnostic criteria with a high coincidence may be used as diagnostic criteria for drug-induced liver injury.However,some cases still can not be diagnosed accurately.Thus they both need further improvement.