乳腺癌新辅助化疗疗效评价体系

目前新辅助化疗已广泛应用于乳腺癌的治疗,可降低肿瘤分期,提高手术切除率和增加保乳手术的机会。恰当的新辅助化疗疗效评价不仅可以指导患者治疗方案和预测预后,还可对不同药物的疗效提供可靠的评估。目前新辅助化疗评估主要采用临床检查如触诊、超声、钼靶X线、计算机断层显像、磁共振成像及病理学检查确定肿瘤体积变化,可分为临床评估和病理学评估。两者均有多种体系标准,未形成统一公认的标准。临床试验中采用较多的标准有WHO和RECIST等临床评价标准以及MP标准和JBCS标准等病理学评价标准。本文就乳腺癌新辅助化疗疗效评估体系进行总结。

The Evaluation System of Neoadjuvant Chemotherapy Therapeutic Effects of Breast Cancer*

Nowadays neoadjuvant chemotherapy is widely used in the treatment of breast cancer in an attempt to down-stage the tumors in order to successfully improve the rate of surgical excision and multiply the chance of breast-conserving surgery.Appropriate evaluation methods for neoadjuvant chemotherapy can not only instruct treatment protocols and predict prognosis,but also provide reliable assessments for different drugs therapeutic effects.Now the evaluation of neoadjuvant chemotherapy mainly adopt clinical examination such as ultrasonograghy,mammograph,computerized tomography,magnetic resonance imaging and pathology examination to determine the change of tumor.Both of the two contain diverse evaluation systems,not achieving one criteria unified and generally acknowledged.Clinical evaluation criteria such as WHO and RECIST and pathological evaluation criteria such as MP and JBCS are widely introduced in clinical trials.In this article,the evaluation systems of neoadjuvant chemotherapy for breast cancer were reviewed and concluded.