奥扎格雷钠联合依达拉奉治疗急性脑梗死的疗效观察

目的:观察奥扎格雷钠联合依达拉奉治疗急性脑梗死的临床疗效。方法:将160例急性脑梗死患者随机分为治疗组和对照组,每组各80例,治疗组采用注射用奥扎格雷钠联合依达拉奉治疗,对照组仅采用注射用奥扎格雷钠治疗,观察两组患者入院及治疗14d后临床疗效,神经功能缺损评分变化并进行对比分析。结果:治疗组的显效率为85.9%(67/78),对照组显效率为70.9%(56/79),两组显效率有显著性差异(x2=5.12,P=0.022),两组患者治疗14d后,神经功能的恢复情况与治疗前相比均有显著性差异(P<0.05),且治疗组与对照组治疗后比较有显著性差异,具有统计学意义(P<0.05)。结论:奥扎格雷钠联合依达拉奉治疗急性脑梗死较单独使用奥扎格雷钠疗效显著,是治疗急性脑梗死的有效方法。

Curative Effect of Ozagrel Sodium Combined with Edaravone in Treating Acute Cerebral Infarction Patients

Objective: To observe the clinical effects of Ozagrel sodium combined with Edaravone in treating acute cerebral in-farction.Methods: 160 patients(92 male and 68 female,mean age of 68years) with noncardioembolic cerebral infarction were randomly divided into two groups,Oz-Ed Group and Control Group,80 cases in each group.Patients in control group were administered only with ozagrel;while patients in Oz-Ed group were administered with ozagrel and edaravone.We evaluated the clinical efficacy of the combination of these drugs in patients,and analyzed the changes of Nerve function defect score from 0 d(before treatment initiation) to 14 d.Results: The effectual rate was 85.9%(67/78)in Oz-Ed group,and was 70.9%(56/79)in control group.There was significant difference between the two groups,x2=5.12,P=0.022.The nerve function recovered much(P<0.05)in both groups after treated for 14 days,as compared with that before treatment.There were also statistically significant difference between the two groups after treatment(P<0.05).Conclusion:Combination therapy with ozagrel and edaravone had a better effect on acute cerebral infarction than single ozagrel therapy.It is an effec-tive therapy for acute cerebral infarction.