核周型抗中性粒细胞胞浆抗体在狼疮性肾炎中的临床意义

目的:探讨核周型抗中性粒细胞胞浆抗体( P-ANCA)在狼疮性肾炎(LN)中的临床意义.方法:应用酶联免疫吸附分析( ELISA)的方法,检测92例LN患者血清中的P-ANCA及其他自身抗体的水平,并进一步分析P-ANCA与LN的临床表现以及辅助检查结果之间的关系.结果:P-ANCA在LN中的阳性率是21.8 ％(20/92),P-ANCA阳性组LN患者合并颧部红斑、皮肤血管炎、贫血以及补体C3偏低的频率均显著高于P-ANCA阴性组LN患者(P＜0.05).结论:P-ANCA在LN中的阳性率为21.8％,且P-ANCA与SLE特定的临床表现相关,提示P-ANCA可能参与了LN的发病过程.

Clinical Significance of Serum Perinuclear Antineutrophil Cytoplasmic Antibodies in Lupus Nephritis

Objective: To elucidate the clinical significance of serum perinuclear antineutrophil cytoplasmic antibodies(P-ANCA) in patients with lupus nephritis(LN).Methods: P-ANCA was detected in serum samples obtained from 92 patients with LN by emzyme-linked immunosorbent assay(ELISA).The relationship between P-ANCA and clinical manifestations and other autoantibodies were analyzed.Results: P-ANCA positive was detected in 21.8 %(20/92) patients.The prevalence of malar rash,cutaneous small vas-culitis,central nervous system involved,anemia and hypocomplementemia were all significantly higher in P-ANCA-positive patients than P-ANCA-negative patients(P<0.05).Conclusions: The prevalence of P-ANCA was 21.8 % in LN and its presence was correlated with particular clinical manifestations,indicating that P-ANCA may play a pathogenetic role in LN.