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急性心肌梗死患者血清cTnI、TNF-α、hs-CRP 水平变化及临床意义
引用本文:蔡民强,杨利红,周祥俊,徐峰,严淑贤.急性心肌梗死患者血清cTnI、TNF-α、hs-CRP 水平变化及临床意义[J].现代生物医学进展,2012,12(15):2940-2942.
作者姓名:蔡民强  杨利红  周祥俊  徐峰  严淑贤
作者单位:1. 上海市长宁区新泾镇社区卫生服务中心 上海200335
2. 复旦大学附属华山医院 上海200040
摘    要:目的:研究急性心肌梗死患者血清心肌肌钙蛋白(IcTnI)、肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP)水平变化及临床意义。方法:对54例急性心肌梗死患者血清cTnI、TNF-α、hs-CRP水平进行检测,并与正常对照组的40例健康受试者进行比较分析。结果:急性心肌梗死组患者发病后6h、12h、24h、48h及72h血清中cTnI、TNF-α、hs-CRP水平均显著高于正常对照组(P<0.05)。其中hs-CRP在患者发病12h后达到高峰,而cTnI、TNF-α均在发病后24h达到高峰;hs-CRP在患者发病早期的检出率较高,发病后6h患者血清hs-CRP检出率与cTnI、TNF-α的差异显著,具有统计学意义(P<0.05)。结论:动态监测急性心肌梗死患者血清cTnI、TNF-α及hs-CRP水平对患者病情评估及治疗措施的选择具有重要的临床意义。

关 键 词:急性心肌梗死  cTnI  TNF-α  hs-CRP

Clinical Significance of Detecting Serum Levels of CTnI,TNF-α and Hs-CRP in Patients with Acute Myocardial Infarction
CAI Min-qiang,YANG Li-hong,ZHOU Xiang-jun,XU Feng,YAN Shu-xian.Clinical Significance of Detecting Serum Levels of CTnI,TNF-α and Hs-CRP in Patients with Acute Myocardial Infarction[J].Progress in Modern Biomedicine,2012,12(15):2940-2942.
Authors:CAI Min-qiang  YANG Li-hong  ZHOU Xiang-jun  XU Feng  YAN Shu-xian
Institution:2(Community Health Service Center of Xinjing Town Changning District,200335,Shanghai,China; 2 Huashan Hospital FuDan University,200040,Shanghai,China)
Abstract:Objective: To study the clinical significance of detecting the serum levels of cTnI,TNF-and hs-CRP in patients with acute myocardial infarction(AMI).Methods: The serum levels of cTnI,TNF-α and hs-CRP were detected in 54 patients with AMI,and compared with those of 40 healthy subjects in the control group.Results: The serum level of cTnI,TNF-α and hs-CRP at 6h,12h,24h,48h and 72h after desease in the AMI group were significantly higher than those in the control group(P<0.05).The serum level of hs-CRP reached the peak at 12h,the serum levels of cTnI and TNF-α reached the peak at 24h;the detection rate of hs-CRP is significantly higher than that of cTnI and TNF-α in the AMI group at 6h(P<0.05).Conclusion: Dynamic monitoring of the serum levels of cTnI,TNF-α and hs-CRP play an important role in the disease assessment and treatment in patients with AMI.
Keywords:Acute myocardial infarction  CTnI  TNF-α  hs-CRP
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