不同劳动者类型脂代谢相关表型的差异分析

目的:比较体力劳动者与脑力劳动者在脂代谢相关表型方面是否有差异。方法:随机抽取泰州市30-75岁个体127例(体力劳动者63例,脑力劳动者64例),进行体力活动日记、身高、体重、腰围、臀围、收缩压、舒张压体格指标测量。取静脉血测量血清空腹血糖(Glu)、总胆固醇(TC)和甘油三酯(TG);使用酶联免疫吸附法测量血清中脂代谢生物标志物低密度脂蛋白受体(LDLR)、载脂蛋白A5(Apo A5)、载脂蛋白B100(Apo B100)、微粒体甘油三酯转运蛋白(MTTP)。采用T检验和卡方检验统计方法比较体力劳动者与脑力劳动者脂代谢相关表型是否有统计学差异。结果:脑力劳动者组的体力活动能量消耗显著低于体力劳动者组(P<0.05),且随着能量消耗等级递增而比例递减(P<0.05)。脑力劳动者组BMI水平显著高于体力劳动者组(P<0.05)。另外,脑力劳动者组在LDLR、Apo A5、Apo B100分子水平都显著低于体力劳动者组(P<0.05)。结论:不同劳动类型影响脂代谢相关表型水平的高低。

Comparison of Lipid Metabolism Related Phenotypes between Two Job Types

Objective: To explore the relationship between job types(brain workers versus manual workers) and metabolic related phenotypes.Methods: 127 participants(30-75 years) were randomly selected from Taizhou city.The participants received a physical examination by trained investigators,including measurement of height,weight,waist and hip circumferences and blood pressure.In addi-tion,we measured the level of 4 lipid metabolism related markers(LDLR,MTTP,Apo A5,Apo B100) using Elisa.The relationship between job types(brain workers versus manual workers) and metabolic related phenotypes were tested by T test and x2 test.Results: There was statistical difference on energy expenditure and BMI between two groups(P<0.05),and energy expenditure in brain workers diminished with increasing energy consumption level.The level of three biological markers(LDLR,Apo A5,Apo B100) between two groups had statistical significance(P<0.05).Conclusions: Job types influence the levels of metabolism related phenotypes.