胆酸钠和依地酸二钠复合用药的溶石效果研究

目的:探讨胆酸钠和依地酸二钠不同摩尔比、胆汁中不同药物浓度、溶解时间与胆管结石溶石效果之间的关系。方法:设计在一个月内胆汁中药物浓度为0.1%的、摩尔比分别为0:1、8:1、4:1、2:1、1:1、1:2、1:4、1:8和1:0的九个等级的胆酸钠和依地酸二钠的溶石实验,摩尔比为1:1的这两种溶石药物在胆汁中药物浓度为0、0.1%、0.2%、0.4%、0.8%、1.6%和3.2%的溶石实验,和摩尔比1:1的溶石药物在胆汁中浓度为0.1%的经过0、1、2、4、8、16、32和64d的溶石实验;评估这三个实验的各自溶石质量是否相等(P<0.05有显著性统计意义)。结果:胆汁中药物浓度、溶石时间相同时,单药依地酸二钠溶石效果比胆酸钠强,复合药物比单药效果好,越靠近摩尔比为1:1时的溶石能力越强,在摩尔比为1:1时溶石能力最强;在相同时间、摩尔比为1:1的复合药物中,药物浓度越大,溶石能力越强;在有充足溶石药物的条件下,相同摩尔比、相同药物浓度,溶解的时间越长,溶石能力越强(P<0.05,有显著性统计意义)。结论:胆酸钠和依地酸二钠摩尔比为1:1时,复合药物具有最大的溶石效果;在有充足溶石药物的条件下,药物浓度越大,溶解的时间越长,溶石能力越强

The Research of Stone Dissolution Effect in Sodium Cholate and Disodium Edetate

Objective: To study the relationship between the dissolution effect of bile duct stones and the different molar ratio of sodium cholate and disodium edetate,drug concentrations,and the time in the bile.Methods:To design the three dissolution experiments that the total drug concentration was 0.1% in the bile within one month,and the molar ratio of sodium cholate and disodium edetate was 0:1,8:1,4:1,2:1,1:1 1:2,1:4,1:8 and 1:0;that the molar ratio was 1:1,and drug concentrations in the bile were 0,0.1%,0.2%,0.4%,0.8%,1.6% and 3.2% in within one month;that that the molar ratio was 1:1,drug concentration was 0.1%,and the time were 0,1,2,4,8,16,32 and 64d.To assess the quality loss of stones in the three experiments was equal(P <0.05 statistical significance).Results:Tt the total drug concentration of 0.1% in one month,disodium edetate dissoluted more stones than sodium cholate,and complex drugs dissoluted more stones than a single agent,and the closer the molar ratio of 1:1,the stronger dissolution ability,the strongest was 1:1.At complex drug of 1:1 in one month,the higher the drug concentration,the stronger dissolution ability.In the conditions of sufficient dissolution drugs,the total drug concentration of 0.1%,and the molar ratio of 1:1,the longer,the more the quality loss of stones(P<0.05,significant statistical significance).Conclusion:When the sodium cholate and sodiumcholate was 1:1,the complex drugs have the strongest dissolution effect;in the condition of sufficient dissolution drugs,the higher the drug concentration,the longer,the more the quality loss of stones.