| 不稳定动脉粥样硬化斑块的研究进展 |
| |
| 引用本文： | 张丹丹,董小黎,杨黎明,刘立新,孟桂霞.不稳定动脉粥样硬化斑块的研究进展[J].现代生物医学进展,2012,12(25):4961-4963. |
| |
| 作者姓名： | 张丹丹 董小黎 杨黎明 刘立新 孟桂霞 |
| |
| 作者单位： | 首都医科大学燕京医学院基础医学系病理教研室;首都医科大学基础医学院病理教研室 |
| |
| 基金项目： | 北京市教委基金(KM200710025006) |
| |
| 摘 要： | 不稳定斑块破裂及继发血栓形成是导致急性心血管事件发生的主要病理基础。不稳定斑块的形成与炎症反应、细胞凋亡等有密切联系,新近研究表明,组织蛋白酶-S、生长相关基因蛋白-α和内质网应激在动脉粥样硬化斑块趋向不稳定的过程中发挥至关重要的作用。本文就相关研究进展进行综述,为深入了解不稳定斑块的形成机制提供依据。
|
| 关 键 词： | 不稳定斑块 组织蛋白酶-S 生长相关基因蛋白-α 内质网应激 |
The Research of Unstable Atherosclerotic Plaque |
| |
| ZHANG Dan-dan,DONG Xiao-li,YANG Li-ming,LIU Li-xin,MENG Gui- xia.The Research of Unstable Atherosclerotic Plaque[J].Progress in Modern Biomedicine,2012,12(25):4961-4963. |
| |
| Authors: | ZHANG Dan-dan DONG Xiao-li YANG Li-ming LIU Li-xin MENG Gui- xia |
| |
| Institution: | 1(1 Department of Pathology,Yanjing Medical College of Capital Medical University,Beijing 101300 China; 2 Department of Pathology,Basic Medical College of Capital Medical University,Beijing 100069 China) |
| |
| Abstract: | Unstable atherosclerotic plaque rupture and subsequent thrombosis are the main patho-reason leading to acute cardio-vascular event occur.There is close relationship between inflammatory reaction,apoptosis and unstable plaque formation.Recent studies show that Cathepsin S,GRO-α and endoplasmic reticulum play important role in the formation of unstable plaque.This article will give a review on this research,to provide the basis for a thorough understanding of the unstable plaque mechanism. |
| |
| Keywords: | Unstable plaque Cathepsin S GRO-α Endoplasmic reticulum |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《现代生物医学进展》浏览原始摘要信息 |
| 点击此处可从《现代生物医学进展》下载免费的PDF全文 |
