牙齿发育与FGF 信号通路的关系

牙齿发育的过程,是一个连续并且复杂的过程。牙齿发育的分子机制可总结为:通过外胚层来源的上皮和其下方的间充质相互作用,来调节牙齿的形态学发生。成纤维细胞生长因子(Fibroblast Growth Factor,FGF)是一类肽类分子,它们通过与细胞膜上特异性受体的结合来发挥作用,以此来调节细胞生长。并且具有多种生物活性,是胚胎生长发育和成体组织创伤修复中最具有重要功能的细胞因子。通过众多科学研究,牙齿发育与FGF信号通路的关系已经研究的比较透彻,在牙齿的生长发育过程中,FGF发挥了关键性作用。

Relationship between Tooth Development and FGF Signaling Pathway

The development of teeth is a continuous and complex course.The molecular mechanism of the teeth development can be concluded as following: Through the interaction between the epithelium from the ectoderm and the mesenchymal tissue,so as to adjust the morphological changes of teeth.Fibroblast Growth Factor(FGF) is a kind of peptide factor.They integrate with the specific receptor on the cell membrane and then become functional on adjusting the growth of cell.They also have various biological activities,and are regarded as the most significant cell factor among the embryonic development and adult tissue trauma repair.Through numerous scientific researches,the connection of teeth growth and FGF signal channel is incisive.It can be said that the FGF plays a key role in the course of teeth development.