首页 | 本学科首页   官方微博 | 高级检索  
   检索      

MicroRNAs-126(miR-126)的生物学功能
引用本文:杨东,张红.MicroRNAs-126(miR-126)的生物学功能[J].现代生物医学进展,2012,12(14):2773-2777.
作者姓名:杨东  张红
作者单位:哈尔滨医科大学 黑龙江哈尔滨150081
基金项目:教育部科学研究重点项目(210062);中国博士后基金(20080440907);黑龙江省政府博士后基金(LRB-0-305)
摘    要:MicroRNAs(MiRNAs)负向调控基因的表达,在细胞分化和细胞功能调节中起着重要作用,且涉及血管新生。应用克隆和测序方法,检测出miR-126在人内皮细胞高度表达。MiR-126与许多肿瘤关系密切,miR-126通过信号传导通路负向调控肿瘤细胞增殖、迁移和侵袭,并且抑制肿瘤生长延长患者存活率;相反的,在某些肿瘤中miR-126也可通过促进肿瘤细胞血管生长加速肿瘤进展,可能是未来作为相关肿瘤治疗的手段之一。本文就miR-126在生理进程和病理进程的表达及其作用进行综述。

关 键 词:miR-126  血管新生  肿瘤

The Biological Function of MicroRNAs-126(miR-126)
YANG Dong,ZHANG Hong.The Biological Function of MicroRNAs-126(miR-126)[J].Progress in Modern Biomedicine,2012,12(14):2773-2777.
Authors:YANG Dong  ZHANG Hong
Institution:(Harbin Medical University,Harbin,150081,China)
Abstract:MicroRNAs(MiRNAs) are negative regulators of gene expression that play a key role in cell-type specific differentiation and modulation of cell function.Some miRNAs have been proposed to be involved in neovascularization,such as miR-126,which has been proved to be specifically and highly expressed in human endothelial cells(EC).MiR-126 is relevant in many tumors and miR-126 have been reported to impair cancer progression through signaling pathways that control tumor cell proliferation,migration,invasion,and survival;Conversely,miR-126 may have a supportive role in the progression of cancer as well,which might be medisted by the promotion of blood vessel growth,and miR-126 may be a novel therapeutic target for relevant diseases.We will summarize the current knowledge of miR-126 for physiological processes and pathological processes here.
Keywords:MiR-126  Neovascularization  Tumor
本文献已被 CNKI 万方数据 等数据库收录!
点击此处可从《现代生物医学进展》浏览原始摘要信息
点击此处可从《现代生物医学进展》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号