小鼠肝部分切除模型

小鼠肝部分切除模型是在经典的大鼠模型基础上发展起来的。随着显微外科技术的发展和小鼠腹部手术围手术期管理的完善,快速、可靠、重复性高的小鼠模型得以建立。因为成本较低,且存在大量为研究肝切除后肝再生的转基因小鼠,小鼠已经成为研究肝再生的重要动物模型。肝再生的调控相当复杂,且不是由单一因素控制的,因此需要多种类的转基因小鼠进行肝切除后肝再生研究来明确各因子在肝再生过程中的确切作用与机制。通过小鼠肝切除后肝再生的研究,目前已证实的参与调控肝再生的细胞因子和生长因子有:肝再生增强因子(ALR)、肿瘤坏死因子α(TNFα)、白介素6(IL-6)、白介素1(IL-1)、肝细胞生长因子(HGF)、去甲肾上腺素(NE)、卵泡抑素(FS)、转化生长因子α(TGF-α)、转化生长因子β-1(TGF-β-1)等。

Models of Partial Hepatectomy in Mice

Partial hepatectomy model in mice is developed on the base of the classic rat model.With the development of microsurgical technique and perioperative management of abdominal surgery in mice,fast,reliable,highly repetitive mouse models have been established.Because of lower cost,there is large varieties of genetically modified mice for the study of liver regeneration after hepatectomy,mice have become an important animal models in the research of liver regeneration.Regulation of liver regeneration is quite complex,and is not controlled by a single factor,therefore studies of liver regeneration after liver resection in a wide array of transgenic mice are needed to clarify the exact role and mechanism of each factor in liver regeneration.Through the study of liver regeneration in mouse liver after resection of cytokines and growth factors involved in the regulation of liver regeneration has been confirmed: Augmenter of liver regeneration(ALR),tumor necrosis factor alpha(TNFα),interleukin 6(IL-6),interleukin 1(IL-1),hepatocyte growth factor(HGF),norepinephrine(NE),follistatin(FS),transforming growth factor alpha(TGF-alpha),transforming growth factor β-1(TGF-beta-1).