人巨细胞病毒IgG 抗体标准品研究进展

人巨细胞病毒(CMV)是威胁人类健康的最重要病原之一。高CMV抗体效价的免疫球蛋白G(IgG)制剂,为临床医生在预防和治疗用药上提供了一个有价值的选择。而CMV免疫球蛋白标准品对于制品的CMV抗体效价测定以及高效价血浆的筛选都至关重要。该标准品对于器官移植/输血安全测试,以及临床诊断都是不可或缺。本综述提供了一种人巨细胞病毒IgG标准品制剂方法以及目前研究进展的概述。此外,本文还关注应用于不同领域的不同CMV IgG抗体效价单位。故本文为人巨细胞病毒免疫球蛋白的开发,人巨细胞病毒IgG抗体诊断试剂的标准化,以及为其质量控制提供参考。

The State of International Standard Material for Cytomegalovirus Immunoglobulin G Determinations

Cytomegalovirus(CMV) remains one of the most important pathogens threatening health of people.Immunoglobulin G(IgG) preparations with high antibody titers against CMV are valuable adjunctive prevention and treatment option for clinicians.The anti-CMV immunoglobulin standard is critical for CMV antibody titer quantification of these preparations and selection of high titer plas-ma.It is also required in testing for both transplantation/transfusion safety and clinical diagnostic purposes.This review provides a sum-mary of the process and current state of anti-Cytomegalovirus IgG standard material preparations.Besides,it sheds a light on the different titer units of anti-Cytomegalovirus immunoglobulin G used in different conditions.Therefore,this paper would give a review on develop-ment of anti-Cytomegalovirus immunoglobulin,the standardization and of diagnostics reagents for anti-Cytomegalovirus IgG and their quality control.