进展性卒中血同型半胱氨酸变化的相关研究

目的:了解各型SIP患者Hcy浓度改变特点的同时,更深一层地探讨各型进展性卒中病情变化与血Hcy水平的关系.方法:抽取SIP组、SIS组脑卒中患者各50名,发病第1,2,3天清晨空腹肘静脉血5mL,采用全自动快速分析仪及其配套Hcy试剂盒,用荧光偏振免疫法测定血浆总Hcy水平.结果:不论是进展性脑卒中还是稳定性脑卒中,与正常相比,Hcy的水平要高于正常组,差异具有显著性,P＜0.01；同时进展性脑卒中与稳定性脑卒中相比较而言,进展性脑卒中的Hcy水平显著高于稳定性脑卒中,P＜0.05.结论:SIP患者Hcy水平显著高于稳定性脑卒中,Hcy增高可能是SIP发展的一个标志.

A Study of the Blood Homocysteine Variational of Stroke in Progression

Objective: To investigate the characteristics of the plasma homocysteinemia(Hcy) concentration in stroke in progress(SIP),and to further explore the relationship between plasma Hcy level and disease condition changes of stroke in progress.Methods: 5ml fasting venous blood were drawn each from 50 SIP patients and 50 SIS patients at the first day,the second day and the third day of attack.Then the plasma Hcy concentrations were measured by using fluorescence polarization immunoassay(FPLA) with full-automatic speedy analyser and its matched Hcy kits.Results: Plasma Hcy concentrations in patients with SIP or SIS were significantly higher than that in the control group(P<0.01).The plasma Hcy concentrations of patients with SIP were also higher than that of patients with SIS(P<0.05).Conclusion: SIP patients had obviously higher plasma Hcy concentrations than SIS patients.The increase of Hcy concentration may be a sign of the SIP development.