GRP94 生物学特点与肿瘤的关系的研究进展

葡萄糖调节蛋白94又叫做内质网蛋白99,是一种内质网分子伴侣蛋白,与HSP90有50%的同源性。GRP94蛋白可以和Ca2+结合具有蛋白伴侣特性,能协助新合成的多肽转位、折叠、寡聚体的组装、降解,抑制错误折叠蛋白的分泌;GRP94还具有抗原呈递的作用,可以作为肿瘤细胞的伴侣蛋白,参与肿瘤细胞的新陈代谢,保护肿瘤细胞免受有害因素的侵害。GRP94可能与人类多种肿瘤的发生有关,其表达的增高可能是肿瘤发生发展的一个重要因素。GRP94在肿瘤组织中高表达提示相关研究者,应用基因手段抑制GRP94的表达可能能够抑制肿瘤细胞的生长、侵袭和转移、增加肿瘤细胞对化疗药物的敏感性等,并且利用GRP94作为一种新的肿瘤治疗的靶分子或介质可能为肿瘤的基因治疗带来更广泛的应用前景。

The Reaserch Progression of the Realationgship between Biological Features of GRP78 and Tumur

Glucose regulated protein 94,also known as the endoplasmic reticulum protein 99,is an endoplasmic reticulum chaperone proteins,and it has 50% homology with HSP90.GRP94 proteins can be combined with Ca2+,having a protein partner properties,which can help a new synthesis of peptide translocation,folding,Assembly and degradation of oligomers,Inhibiting secretion of Protein misfolding;GRP94,also has antigen presenting function,can be used as tumor cells of chaperone proteins,involving in tumor cells of the new supersedes the old,protecting tumor cells from harmful factors of infringement.GRP94 may be associated with a variety of human tumors,its increased expression may be an important factor in tumor occurrence and development.The high expression of GRP94 in tumor tissues indicated that inhibiting the expression of GRP94 by gene technology may restrain the tumor cells’ growth,invasion and metastasis,increase tumor cell sensitivity to chemotherapeutic drugs.And GRP94 as a kind of new cancer treatment target molecules or medium for cancer gene therapy may bring more extensive application prospect.