急性肾损伤患者血清胱抑素-C及尿NGAL 水平的变化及其临床意义

目的:观察急性肾损伤(Acute kidney injury,AKI)患者血清胱抑素-C(Cystatin-C,CysC)及尿中性粒细胞明胶酶相关脂质运载蛋白(Neutrophil gelatinase-associated lipocalin,NGAL)水平的变化及其临床意义。方法:选择60例AKI患者为实验组,50例正常健康人作为对照组,应用酶联免疫吸附法测定两组人群血清胱抑素-C和尿NGAL水平。结果:实验组与对照组相比血清胱抑素-C和尿NGAL水平显著升高,差异有统计学意义(P<0.05)。实验组尿NGAL检出率高于血清胱抑素-C、血肌酐,差异有统计学意义(P<0.05)。结论:急性肾损伤患者血清胱抑素-C和尿NGAL均升高,其中尿NGAL是反映AKI较敏感的生物学标志物,值得临床进一步研究。

The Serum Cystatin-C and Urinary NGAL Levels and its Clinical Significance of Acute Kidney Injury the Patients of Acute Kidney Injury

Objective: To observe the serum cystatin-C(CysC) and the urinary neutrophil gelatinase-associated lipocalin(NGAL) level of the patients of the acute kidney injury(AKI) and to assess its clinical significance.Methods: We chose 60 patients of AKI as the experimental group,and 50 healthy people as thecontrol group.The serum cystatin-C and urinary NGAL levels of two groups were detected by enzyme-linked immunosorbent assay.Results: Compared with the control group,theserum cystatin-C and urinary NGAL levels significantly increased,and the differences were statistically significant(P <0.05).The urinary NGAL detection rate was higher than serum cystatin-C,serum creatinine of experimental group,and the difference was statistically significant(P <0.05).Conclusion: Theserum cystatin-C and urinary NGAL of the patients of AKI were both increased,and the urinary NGAL was a more sensitive than the serum cystatin-C,and it is worthy studying further.