中西医联合治疗慢性再生障碍性贫血临床观察

目的:探讨中药血复生联合西药治疗慢性再生障碍性贫血(CAA)的临床效果,及对造血、细胞免疫功能和血清IL-2、IFN-γ的影响。方法:将54例慢性再生障碍性贫血分为联合治疗组与对照组,其中对照组给予西药常规治疗,联合治疗组在此基础上加用血复生,通过观察治疗前后患者临床症状、外周血象、T-淋巴细胞亚群和血清IL-2、IFN-γ水平变化,比较两组疗效。结果:联合治疗组总有效率为88.24%,显著高于对照组65.00%的总有效率(P<0.01),联合治疗组在症状改善、升高全血细胞、调节T-淋巴细胞亚群和降低血清IL-2、IFN-γ水平等方面作用优于对照组(P<0.01或0.05),且不良反应少。结论:血复生联合西药可促进CAA患者造血细胞增殖,调节细胞免疫功能,效果好于单用西药。

Clinical Investigation on Xuefusheng Combined with Western Medicine in the Treatment of Chronic Aplastic Anemia

Objective: To explore the clinical effects of combined treatment of Xuefusheng and western medicine on chronic aplastic anemia(CAA),as well as the impact on hemopoiesis,cellular immune function and serum levels of IL-2,IFN-γ.Methods: 54 CAA patients were divided into combined-treatment group and control group.The control group was treated with conventional western medicine,and the treatment group with conventional western medicine plus Xuefusheng.To compare the clinical efficiency between the two groups,the changes in clinical symptoms,peripheral hemogram,T-lymphocyte subsets and levels of IL-2,IFN-γ were evaluated before and after treatment.Results: The total effective rate in the combined-treatment group(88.24%) were significantly higher than control group(65.00%)(P<0.01).And the combined-treatment group showed better effects than control group in improving clinical symptoms,elevating complete blood cells,regulating T-lymphocyte subsets,and reducing levels of serum IL-1,IFN-γ(P<0.01 or 0.05),with fewer side effects.Conclusion: Xuefusheng combined with conventional western medicine could enhance the hematopoietic cells proliferation and regulate the cellular immune function in CAA patients,better than western medicine used alone.