血浆超敏CRP 和血清半胱氨酸蛋白酶抑制剂C 联合检测对冠心病患者 的意义

目的:探讨超敏CRP(hs-CRP)、半胱氨酸蛋白酶抑制剂C(CysC)联合检测对冠心病患者的意义。方法:收集120例冠心病(Coronary heart disease,CHD)患者(其中不稳定型心绞痛unstablangina,UA 62例,急性冠状动脉综合征AcuteCoronarySyndrome,ACS 48例,)选择60例性别、年龄、居住地等与冠心病组相匹配的正常者为对照组,测定hs-CRP、CysC水平。结果:hs-CRP、CysC水平在正常对照组、稳定型心绞痛组、急性冠状动脉综合征组中依次增高,恢复后hs-CRP比CysC下降的速度更快,CysC在恢复期更能提醒病人的预后情况,冠心病组与正常对照相比有统计学意义(P<0.01),治疗后与治疗前hs-CRP、CysC的浓度相比(P<0.01)差异有显著性。治疗后hs-CRP敏感度分别为20.96%、24.19%;CysC敏感度分别为47.91%、52.08%。结论:hs-CRP、CysC与CHD发生、发展密切相关,联合检测有利于冠心病的早期诊断。对于临床的分型和病情的发展及预后的观察有极其重要的意义。

The Significance of Joint Detection with Hs-CRP and Cysc for CHD Patients

Objective: To investigate the significance of joint detection with hs-CRP and Cystatin C for CHD patients.Methods: 120 cases of CHD(62 UA cases and 48 ACS cases) were collected to determine CRP and Cystatin C levels,and 60 patients were used as normal control group,with their gender,age,place of residence matched with CHD.Results: CRP,CysC levels increased in order in the normal control group,the group with stable angina pectoris,acute coronary syndrome group.Hs-CRP level declines faster than CysC when patients recovered,CysC level is more obvious in the rehabilitation period to remind the patient’s prognosis,better in coronary heart disease group than normal control group.CysC and hs-CRP concentration was significant different before and after the cure.After treatment,hs-CRP sensitivity was respectively 20.96% and 24.19%,while CysC sensitivity was respectively 47.91% and 52.08%.Conclusions: Hs-CRP and Cys C levels are closely related to the occurrence and development of CHD.Joint detection will help the early diagnosis of coronary artery disease,and it is extremely important for clinical classification,development of the disease and prognosis.