| 乌灵胶囊对抑郁大鼠脑组织中乙酰化H3 及5-HTT、TH 表达的影响 |
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| 引用本文： | 黎功炳,雷宁,覃树勇,龙军,陈德书,易伟.乌灵胶囊对抑郁大鼠脑组织中乙酰化H3 及5-HTT、TH 表达的影响[J].现代生物医学进展,2012,12(19):3642-3644. |
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| 作者姓名： | 黎功炳 雷宁 覃树勇 龙军 陈德书 易伟 |
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| 作者单位： | 1. 重庆市大足区妇幼保健院 重庆402360
2. 成都理工大学材料与化学化工学院化工与制药系 四川成都610059 |
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| 摘 要： | 目的:观察乌灵胶囊对抑郁大鼠脑组织中乙酰化组蛋白H3及5-羟色胺受体(5-HTT)、酪氨酸羟化酶(tyrosine hydroxylase,TH)表达的影响。方法:SD大鼠随机分为对照组、模型组及乌灵胶囊低、高剂量组。取大鼠脑组织,分别采用实时荧光定量PCR法和western blot法检测脑组织中乙酰化组蛋白H3、组蛋白H3,5-HTT、TH蛋白和mRNA的表达。结果:乌灵胶囊明显增强大鼠脑组织中乙酰化组蛋白比例和5-HTT、TH蛋白和mRNA的表达(P<0.05)。结论:乌灵胶囊治疗抑郁症的机制可能与升高脑组织乙酰化组蛋白含量,从而促进5-HTT、TH的表达有关。
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| 关 键 词： | 抑郁 5-HTT TPH 乌灵胶囊 组蛋白H3 |
The Effect ofWuling Capsule on the Expression of Acelyl Histone H3,
5-HTT and TH in the Brain Tissue of Depressed Rats |
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| LI Gong-bing,LEI Ning,QIN Shu-yong,LONG Jun,CHEN De-shu,YIWei.The Effect ofWuling Capsule on the Expression of Acelyl Histone H3,
5-HTT and TH in the Brain Tissue of Depressed Rats[J].Progress in Modern Biomedicine,2012,12(19):3642-3644. |
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| Authors: | LI Gong-bing LEI Ning QIN Shu-yong LONG Jun CHEN De-shu YIWei |
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| Institution: | 1(1 Maternal and Child Care Service Centre of Dazu county,Chongqing,402360; 2 Department of Chemical & Pharmaceutical Engineering,College of Material and Chemistry and Chemical Engineering, Chengdu University of Technology,Sichuan,Chengdu 610059,China) |
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| Abstract: | Objective: To observe the effect of Wuling capsule on the expression of acelyl histone H3,5-HTT and TH in the brain tissue of depressed rats.Methods: Rats were divide into control,model and two doses groups of Wuling capsule.Contents of acelyl histone H3,histone H3,5-HTT and TH mRNA and protein in he brain tissue of depressed rats were measured by realtime RT-PCR and western blot methods,respectively.Results: Wuling capsule could increase the expression of acelyl histone H3,5-HTT and TH mRNA and protein in the brain tissue of depressed rats.Conclusion: Wuling capsule could cure athymia,this maybe concerned with its effect on acelyl histone H3,5-HTT and TH expression. |
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| Keywords: | Athymia 5-HTT TPH Wuling capsule Histone H3 |
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