| Wnt 信号通路GS 蛋白在胃癌中的表达和临床意义 |
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| 引用本文： | 李雪,张巍巍,耿长新,解祥军,司君利,王青.Wnt 信号通路GS 蛋白在胃癌中的表达和临床意义[J].现代生物医学进展,2011,11(10):1913-1916. |
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| 作者姓名： | 李雪 张巍巍 耿长新 解祥军 司君利 王青 |
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| 作者单位： | 1. 青岛大学医学院附属青岛市市立医院消化科,山东,青岛,266071
2. 青岛大学附属青岛市市立医院科研科,山东,青岛,266071 |
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| 摘 要： | 目的:研究Wnt信号通路的中GS蛋白(谷氨酰胺合成酶)在胃癌组织中的表达,探索其在胃癌发生、发展中的意义。方法:用免疫组织化学法测定胃癌组织(110例)、肠化生组织(30例)、不典型增生组织(20例)及慢性浅表性胃炎组织(60例)中GS蛋白表达。用快速尿素酶法与病理组织切片染色法检测上述各组织中HP感染的情况,并予统计学分析比较其差异。结果:胃癌组织GS高蛋白表达与组织分型、分化程度、淋巴结转移密切相关(P<0.05),与肿瘤大小、部位、TNM分期、Borrmann分型、性别、年龄等无明显相关(P>0.05)。GS表达与HP感染密切相关。结论:GS蛋白高表达同胃癌生物学行为密切相关,在胃癌的发生、发展中起重要作用。
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| 关 键 词： | Wnt信号通路 胃癌 谷氨酰胺合成酶(GS) 幽门螺杆菌 |
Expression of Target GS Protein in WNT Signaling Pathway in Gastric
Cancer and Its Clinical Signlficance |
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| LI Xue,ZHANG Wei-wei,GENG Chang-xin,XIE Xiang-jun,SI Jun-li,WANG Qing.Expression of Target GS Protein in WNT Signaling Pathway in Gastric
Cancer and Its Clinical Signlficance[J].Progress in Modern Biomedicine,2011,11(10):1913-1916. |
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| Authors: | LI Xue ZHANG Wei-wei GENG Chang-xin XIE Xiang-jun SI Jun-li WANG Qing |
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| Institution: | 1△(1Department of Gastroenterology,Qingdao Municipal Hospital Affiliated to Qingdao University Medical College,Qingdao 266071,Shandong,China;2 Sience and Research Division,Qingdao Municipal Hospital Affiliated to Qingdao University Medical College,Qingdao 266071,Shandong,China) |
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| Abstract: | Objective:To investigate the new target of Wnt signaling pathway Glutamine synthetase(GS) protein expression in the Gastric cancer tissues and to explore its significance in the development of gastric cancer.Methods:Immunohistochemistry(SP method) was used to detect GS expression in paraffin-embedded gastric cancer tissues of 110 cases,intestinal metaplasia tissues of 30 cases,dysplasia tissues of 20 cases,chronic superficial gastritis tissues of 30 cases.Rapid urease and histopathologic staining method wer... |
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| Keywords: | Wnt signaling pathway Gastric cancer Glutamine synthetase(GS) Helicobacter pylori(HP) |
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