靖江地区宫颈病变患者高危型人乳头瘤病毒感染及其基因型分析

目的:研究靖江地区各组宫颈病变中高危型人乳头瘤病毒(HPV)感染率及其基因型分布。方法:采用实时荧光PCR检测方法检测334例宫颈脱落细胞标本中高危型HPV及其基因型。结果:高危型HPV在宫颈炎组、湿疣组、低度鳞状上皮细胞内病变(LSIL)组、高度鳞状上皮细胞内病变(HSIL)组中的感染率分别为24.2%、58.2%、49.3%、69.5%;HPV 16、18、33、58型在宫颈病变中是最常见的HPV型别,其中,HPV16型在宫颈炎组、湿疣组、LSIL组、HSIL组中所占比例逐渐增高,分别为17.9%、18.9%、30.8%、41.9%。结论:高危型HPV感染率随着宫颈病变程度的加重而升高,HPV16型是高危型HPV感染中的主要亚型,HPV18、33、52、58也较常见,其余型别很少。

Infection Rate Human Papilloma Virus and Genotype Distribution of Patients with Cervical Lesions in Jingjiang Area

Objective: To study the infection rate of human papilloma virus and genotype distribution of patients with cervical lesions in Jingjiang area. Methods: Detect the high-risk HPV types and genotype in 334 cervical specimens of routine Pap with Real-Time PCR. Results: The infection rate of high-risk HPV types in cervicitis group, condyloma group, LSIL group,HSIL group was 24.2%,58.2%,49.3%,69.5%, respectively. The most common genotype in cervical lesions is HPV 16,18,33,58;in which, the infection rate of HPV16 in cervicitis group,condyloma group,LSIL group,HSIL group was 17.9%,18.9%,30.8%,41.9%, respectively. Conclusion: The infection rate of high-risk HPV increases with the severity of cervical lesions. HPV16 is the main genotype of the high-risk HPV infection. The other HPV types are more common.