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| 围手术期不同处理因素对SD 大鼠肠道菌群的影响 | |
| 引用本文： | 王亮,沈丽,王东升,韩立慧,王茂龙,刘汉成,周岩冰.围手术期不同处理因素对SD 大鼠肠道菌群的影响[J].现代生物医学进展,2011,11(10):1924-1926. |
| 作者姓名： | 王亮 沈丽 王东升 韩立慧 王茂龙 刘汉成 周岩冰 |
| 作者单位： | 1. 青岛大学医学院附属医院普外科,山东,青岛,266003 2. 青岛大学医学院附属医院眼科,山东,青岛,266003 3. 青岛大学医学院附属医院内分泌科,山东,青岛,266003 |
| 摘 要： | 目的:探讨抗生素、肠道准备以及饮食对SD大鼠肠道菌群的影响。方法:将36只SD大鼠随机分为6组,分别采用不同的处理措施,分为对照组,抗生素组,肠道准备组,禁饮食组,术后早期禁饮食组和术后早期进食组,共处理4天,第5天脱颈椎处死,无菌条件下取回盲部粪便进行细菌培养并计数。结果:抗生素组、肠道准备组以及禁饮食组与对照组比较,抗生素组与肠道准备组、禁饮食组比较,大肠杆菌、类杆菌数量均明显增加,双歧杆菌、肠球菌数量均显著减少,双歧杆菌/大肠杆菌比值显著降低;其差异有统计学意义(P<0.05);术后早期进食组与术后禁饮食组相比,大肠杆菌、类杆菌数量有所减少,双歧杆菌、肠球菌数量有所增加,双歧杆菌/大肠杆菌比值有所提高,且其差异有统计学意义(P<0.05)。结论:抗生素、肠道准备以及禁饮食均可引起SD大鼠肠道菌群失调,其中抗生素对肠道菌群的影响最大;并且术后早期进食对肠道菌群失调有改善作用。 |
| 关 键 词： | 肠道菌群 抗生素 肠道准备 禁饮食 |
Effects of Different Perioperative Managements on the Intestinal Flora in Rats |
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| WANG Liang,SHEN Li,WANG Dong-sheng,HAN Li-hui,WANG Mao-long,LIU Han-cheng,ZHOU Yan-bing.Effects of Different Perioperative Managements on the Intestinal Flora in Rats[J].Progress in Modern Biomedicine,2011,11(10):1924-1926. | |
| Authors: | WANG Liang SHEN Li WANG Dong-sheng HAN Li-hui WANG Mao-long LIU Han-cheng ZHOU Yan-bing |
| Institution: | WANG Liang1,SHEN Li2,WANG Dong-sheng1,HAN Li-hui3,WANG Mao-long1,LIU Han-cheng1,ZHOU Yan-bing1△(1 Department of general surgery,2 Department of ophthalmology,3 Department of endocrinology,The Affiliated Hospital of Medical College of QingDao University,Sh,ong Province,Qingdao,266003 |
| Abstract: | Objective:To investigate the influence of antibiotics,bowel preparation,and abrosia on intestinal flora of SD rats.Methods:36 SD rats were randomly divided into 6 groups:control group,antibiotics group,bowel preparation group,abrosia group,bowel preparation-antibiotics-operation-abrosia after the operation(called postoperative abrosia group) and bowel preparation-antibiotics-operation-eating after the operation(called postoperative food processing group).Next,all of the rats had been adopted different dispo... |
| Keywords: | Intestinal flora Antibiotics Bowel preparation Abrosia |
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