小胶质细胞在帕金森病病理进展中的作用

帕金森病是中老年人常见的中枢神经系统退行性疾病,研究表明小胶质细胞的活化及其介导的神经炎症在帕金森病的病程进展中发挥重要作用,适度干预小胶质细胞的活化有望延缓帕金森病的进程。小胶质细胞是中枢神经系统固有的巨噬细胞,Notch信号途径可以调控小鼠外周巨噬细胞的分化及功能。Notch通路也参与调控小胶质细胞的激活、细胞因子的表达、吞噬活性的变化等,而这与活化的小胶质细胞介导的帕金森病等神经退行性疾病的病情进展相关。因此,本文将综述Notch信号途径与小胶质细胞介导的相关疾病的研究进展。

The Role of Microglia in the Progress of Parkinson's Disease

Parkinson''s disease (PD) is a common neurodegeneration disease among more than 65-year old people. Some studies indicate that the activation of microglia and the neuroinflammation mediated by it play a critical role in the onset and progression of PD, and intervention of the activation process of microglia could possibly attenuate the progression of PD. Microglia is the resident macrophage in central nervous systerm (CNS). Notch signaling pathway can modulate the differentiation and function of macrophages in mice. It is also reported that the Notch signaling pathway can modulate the function of microglia in activation, expression of cytokines, phagocytosis ability, and so on. And this is related with activated microglia mediated neurodegenerative diseases such as PD. Therefore, research works about the relation between Notch signaling pathway and activated microglia-mediated diseases is of great significance. Key words: Parkinson''s disease; Neuroinflammation; Microglia; Notch signaling pathway