重度抑郁症患者血清CXCL1、CCL11水平与生活事件和自杀意念的关系研究

摘要 目的：探讨重度抑郁症（MDD）患者血清CXC趋化因子配体1（CXCL1）、CC趋化因子11（CCL11）水平与生活事件和自杀意念的关系。方法：选取2020年1月-2021年6月我院收治的MDD患者100例作为病例组，选取同期100例健康体检的志愿者作为对照组，比较两组研究对象的血清CXCL1、CCL11水平、生活事件量表（LES）评定结果，采用Pearson法分析LES评定结果与CXCL1、CCL11水平的相关性。100例MDD患者根据有无自杀意念，分为自杀意念组（n=45）和无自杀意念组（n=55），采用单因素及多因素Logistic回归分析MDD患者自杀意念相关影响因素。结果：病例组患者血清CXCL1、CCL11水平，负性事件刺激量、生活事件应激总分高于对照组（P＜0.05），正性事件刺激量低于对照组（P＜0.05）；血清CXCL1、CCL11水平与负性事件刺激量呈正相关（P＜0.05）；本研究调查结果显示，MDD患者调查期间自杀意念发生率为45.00%，自杀意念组患者性别、自杀未遂史、病程、合并焦虑症状、精神质、神经质、内外向、掩饰性、CXCL1、CCL11、负性事件刺激量、生活事件应激总分与无自杀意念组比较差异有统计学意义（P＜0.05），多因素Logistic回归分析结果显示，性别、精神质、神经质，血清CXCL1、CCL11水平，负性事件刺激量是MDD患者自杀意念发生的影响因素。结论：MDD患者血清CXCL1、CCL11水平升高，血清CXCL1、CCL11水平与负性事件刺激量存在一定的相关性，MDD患者出现自杀意念的概率较高，且血清CXCL1、CCL11水平及负性事件刺激量等均是其自杀意念发生的影响因素，临床工作中应针对相关影响因素积极采取应对措施。

Research on the Relationship between Serum CXCL1 and CCL11 Levels and Life Events and Suicidal Ideation in Patients with Major Depressive Disorder

ABSTRACT Objective: To explore the relationship between serum C-X-C motif chemokine ligand 1 (CXCL1) and C-C motif chemokine 11 (CCL11) levels and life events and suicidal ideation in patients with major depressive disorder (MDD). Methods: The 100 patients with MDD who were admitted to our hospital from January 2020 to June 2021 were selected as the case group, and 100 volunteers who underwent physical examination in our hospital in the same period were selected as the control group. The serum CXCL1 and CCL11 levels and the life event scale(LES) evaluation results were compared between the two groups of subjects. Pearson method was used to analyze the correlation between LES evaluation results and CXCL1 and CCL11 levels. 100 patients with MDD were divided into suicide ideation group (n=45) and non-suicide ideation group (n=55) according to whether they had suicide ideation. The related influencing factors of suicide ideation in patients with MDD were analyzed by univariate and multivariate Logistic regression. Results: The serum CXCL1, CCL11 levels, negative event stimulation amount and life event stress total score in case group were higher than those in control group(P<0.05), while positive event stimulation amount was lower than that in control group(P<0.05). The serum CXCL1 and CCL11 levels were positively correlated with the negative event stimulation amount(P<0.05). The results of this study showed that the incidence of suicidal ideation in patients with MDD was 45.00% during the investigation period. There were statistically significant differences in gender, family history of suicide attempt, combined with anxiety symptoms, psychoticism, neuroticism, introversion-extroversion, cover-up, CXCL1, CCL11, negative event stimulation amount and life event stress total score between the suicidal ideation group and the non-suicidal ideation group(P<0.05). Multivariate Logistic regression analysis showed that gender, psychoticism, neuroticism, serum CXCL1 and CCL11 levels and negative event stimulation amount were the influencing factors for the occurrence of suicidal ideation in patients with MDD. Conclusion: The serum CXCL1 and CCL11 levels in patients with MDD are increased. There is a certain correlation between the serum CXCL1 and CCL11 levels and negative event stimulation amount. The patients with MDD have a high probability of suicidal ideation, and the serum CXCL1 and CCL11 levels and negative event stimulation amount are the influencing factors of suicidal ideation. In clinical work, we should actively take countermeasures against the relevant influencing factors.