脾氨肽辅助抗结核药物治疗肺结核的临床疗效观察

摘要 目的：观察脾氨肽辅助抗结核药物治疗肺结核的临床疗效。方法：随机数值表法将2016年6月～2021年6月本院收治的120例肺结核患者分为观察组、对照组。对照组予常规抗结核药物治疗，观察组予脾氨肽辅助抗结核药物治疗。评价两组肺部病灶变化情况、肺部空洞变化情况；检测两组治疗2、4、6个月时痰培养转阴率；检测两组治疗前后外周血T淋巴细胞亚群CD3⁺、CD4⁺及CD4⁺/CD8⁺比值。结果：观察组肺部病灶变化、肺部空洞变化疗效的总有效率分别为95.00%、93.33%，明显高于对照组的83.33%、80.00%（P＜0.05）。两组在治疗6个月时的痰培养转阴率无显著差异（P＞0.05），但观察组在治疗2、4个月时的痰培养转阴率均显著高于对照组（P＜0.05）。两组治疗前及对照组治疗前后的CD3⁺、CD4⁺及CD4⁺/CD8⁺比值比较无明显差异（P＞0.05），但观察组治疗后的CD3⁺、CD4⁺及CD4⁺/CD8⁺比值均显著高于本组治疗前及对照组治疗后（P＜0.05）。结论：脾氨肽辅助抗结核药物治疗肺结核有助于提升临床疗效，可能与提升患者的免疫功能水平有关，值得临床进一步研究。

Clinical Effect of Anti-tuberculosis Drugs Assisted with Spleen Aminopeptide in the Treatment of Tuberculosis

ABSTRACT Objective: To observe the clinical curative effect of anti-tuberculosis drugs assisted with spleen aminopeptide on tuberculosis. Methods: According to random number table method, 120 patients with tuberculosis admitted to the hospital were divided into observation group and control group between June 2016 and June 2021. The control group was treated with routine anti-tuberculosis drugs, while observation group was additionally treated with spleen aminopeptide. The changes of lung lesions and cavities in both groups were evaluated. The negative conversion ratios of sputum culture after 2, 4 and 6 months of treatment, peripheral blood T lymphocyte subsets (CD3⁺⁺⁺+Results: The total response rates of lung lesions and lung cavities in observation group were 95.00% and 93.33%, significantly higher than those in control group (83.33%, 80.00%) (P<0.05). After 6 months of treatment, difference in negative conversion ratio of sputum culture between the two groups was not statistically significant(P>0.05). After 2 and 4 months of treatment, negative conversion ratios of sputum culture in observation group were significantly higher than those in control group(P<0.05). The difference in CD3⁺⁺++0.05). After treatment, CD3⁺⁺++Conclusion: The anti-tuberculosis drugs assisted with spleen aminopeptide are beneficial to improve clinical curative effect on tuberculosis, which may be related to enhancing immune function. And it is worthy of further clinical research.