胃肠道间质瘤组织S100A4、CD55的表达及与临床病理参数及预后的关系研究

摘要 目的：探讨胃肠道间质瘤组织S100A4、衰变加速因子（CD55）的表达及与临床病理参数及预后的关系。方法：选取2011年1月-2015年12月在陆军军医大学附属西南医院江北院区/陆军第958医院行手术切除并经术后病理确诊的124例GIST组织和对应的瘤旁正常组织病理蜡块，采用免疫组化法检测S100A4、CD55在GIST组织及瘤旁正常组织中的表达，分析其表达与GIST患者临床病理参数及预后的关系。结果：S100A4、CD55在GIST组织中的高表达率明显高于瘤旁正常组织，差异有统计学意义（P<0.05）。S100A4、CD55表达与GIST患者肿瘤大小、核分裂相、NIH分级及远处转移有关（P<0.05），与GIST患者年龄、性别、发生部位、组织学类型无关（P>0.05）。S100A4、CD55低表达的GIST患者术后复发率和转移率低于S100A4、CD55高表达的GIST患者，差异有统计学意义（P<0.05）；S100A4、CD55低表达组患者5年中位无进展生存期明显高于S100A4、CD55高表达组，差异有统计学意义（P<0.05）。结论：S100A4、CD55在GIST组织存在高表达， 二者可能参与了GIST的侵袭与转移，并与患者术后的预后有关。

Expression of S100A4 and CD55 in Gastrointestinal Stromal Tumors and Their Relationship with Clinicopathological Parameters and Prognosis

ABSTRACT Objective: To investigate the expression of S100A4 and decay-accelerating factor(CD55) in gastrointestinal stromal tumors(GIST) and their relationship with clinicopathological parameters and prognosis. Methods: From January 2011 to December 2015, 124 cases of GIST tissue and corresponding adjacent normal tissue pathological wax block in Jiangbei District of Southwest Hospital Affiliated to Army Medical University/958 Hospital of PLA were selected, which were surgically resected and pathologically confirmed. Immunohistochemistry was used to detect the expression of S100A4 and CD55 in GIST tissue and adjacent normal tissues.The relationship between the expression of S100A4 and CD55 and clinicopathological parameters and prognosis of GIST patients was analyzed. Results: The high expression rates of S100A4 and CD55 in GIST tissues were significantly higher than those in adjacent normal tissues(P<0.05). The expression of S100A4 and CD55 were correlated with tumor size, mitotic phase, NIH grade and distant metastasis(P<0.05), but not with age, gender, location and histological type (P>0.05). The recurrence rate and metastasis rate of GIST patients with low expression of S100A4 and CD55 were lower than those with high expression of S100A4 and CD55,and the difference was statistically significant (P<0.05); the 5-years median progression free survival of patients with low expression of S100A4 and CD55 was significantly higher than those with high expression of S100A4 and CD55, and the difference was statistically significant(P<0.05). Conclusion: S100A4 and CD55 are highly expressed in GIST tissues, which may be involved in the invasion and metastasis of gist and related to the prognosis of patients after operation.