硫酸镁联合小剂量阿司匹林治疗子痫前期效果及子宫动脉血流、胎盘VEGF、MMP-9表达影响研究

摘要 目的：探讨硫酸镁联合小剂量阿司匹林治疗子痫前期效果及子宫动脉血流、胎盘血管内皮生长因子（VEGF）、基质金属蛋白酶-9（MMP-9）表达影响研究。方法：选择2019年6月-2021年1月在我院接受治疗的125例子痫前期患者，采用随机数表法分为试验组（n=63）和对照组（n=62）。对照组给硫酸镁治疗，试验组在对照组的基础上联合小剂量阿司匹林治疗。比较两组临床疗效、子宫动脉血流、胎盘VEGF、MMP-9、血压水平变化情况及妊娠不良结局发生情况。结果：治疗后，两组总有效率比较差异显著（P<0.05）；治疗前，试验组和对照组子宫动脉指标水平比较无显著差异；治疗后，试验组和对照组RI、PI及S/D水平均随着时间的推移而升高，且试验组均高于对照组，差异显著（P<0.05）；治疗前，试验组和对照组胎盘VEGF、MMP-9水平比较无显著差异；治疗后，试验组和对照组胎盘VEGF、MMP-9水平均随着时间的推移而升高，且试验组均高于对照组，差异显著（P<0.05）；治疗前，试验组和对照组血压水平比较无显著差异；治疗后，试验组和对照组血压水平均随着时间的推移而降低，且试验组均低于对照组，差异显著（P<0.05）；试验组胎儿窘迫、宫缩乏力及新生儿窒息发生率均显著低于对照组，差异显著（P<0.05）。结论：在子痫前期中应用硫酸镁联合小剂量阿司匹林治疗疗效显著，可有效改善患者子宫动脉血流、胎盘VEGF、MMP-9水平。

Effect of Magnesium Sulfate Combined with Low-dose Aspirin in the Treatment of Preeclampsia and Influence of Uterine Artery Blood Flow, Placental VEGF and MMP-9 Expression

ABSTRACT Objective: To study Effect of magnesium sulfate combined with low-dose aspirin in the treatment of preeclampsia and influence of uterine artery blood flow, placental Vascular Endothelial growth factor (VEGF), Matrix Metalloproteinase-9 (MMP-9) expr- ession. Methods: 125 patients with prelampsia who received treatment in our hospital from June 2019 to January 2021 were selected and divided into experimental group (n=63) and control group (n=62) by random number table method. The control group was treated with magnesium sulfate, and the experimental group was treated with low-dose aspirin in addition to the control group. Clinical efficacy, uterine artery blood flow, placental VEGF, MMP-9, blood pressure and adverse pregnancy outcomes were compared between the two groups. Results: After treatment, the total effective rate of the two groups was significantly different (P<0.05); Before treatment, there was no significant difference in uterine artery indexes between experimental group and control group. After treatment, RI, PI and S/D levels in experimental group and control group were increased over time, and the experimental group was higher than the control group, the difference was significant(P<0.05); Before treatment, there were no significant differences in placental VEGF and MMP-9 levels between experimental group and control group. After treatment, the levels of placental VEGF and MMP-9 in experimental group and control group were increased over time, and the levels in experimental group were higher than those in control group, the difference was significant(P<0.05); Before treatment, there was no significant difference in blood pressure between the experimental group and the control group. After treatment, the blood pressure level of both experimental group and control group decreased over time, and the experimental group was lower than the control group, the difference was significant(P<0.05); The incidence of fetal distress, uterine weakness and neonatal asphyxia in experimental group were significantly lower than those in control group(P<0.05). Conclusion: Magnesium sulfate combined with low-dose aspirin is effective in the treatment of preeclampsia, which can effectively improve the levels of uterine artery blood flow, placental VEGF and MMP-9.