DTI和功能磁共振成像对精神分裂症患者脑功能连接强度的临床研究

摘要 目的：探讨DTI和功能磁共振成像对精神分裂症患者脑功能连接强度的临床研究。方法：选取2017年9月-2021年3月在我院精神科就诊的精神分裂患者96例。将纳入的96例患者作为精神分裂组，选择同时期招募的96例健康志愿者作为对照组。使用FMRIB软件库进行结构数据预处理和脑解剖网络构建，并进行相关的分析。结果：精神分裂组较对照组枕叶模块功能连接强度增强，较对照组皮质模块和额顶叶模块功能连接强度减弱（P<0.05），精神分裂组与对照组的默认模块和中央模块功能连接强度比较无差异（P>0.05）。精神分裂组与对照组各模块的结构连接强度比较无差异（P>0.05）。精神分裂组较对照组默认模式模块和中央模块的结构-功能连接程度增加，精神分裂组较对照组枕叶模块和皮质模块的结构-功能连接程度降低（P<0.05），额顶叶模块结构-功能连接程度两组比较无差异（P>0.05）。在精神分裂症组中，枕叶模块的结构-功能连接评分与疾病持续时间（r=-0.528，P=0.006）和PANSS总体症状相关（r=-0.174，P=0.003），皮质模块的结构-功能连接评分也与PANSS整体症状（r=-0.405，P=0.034）显著负相关。皮质模块的结构-功能连接评分与疾病持续时间之间显著负相关（r=-0.336，P=0.029）。结论：精神分裂症患者的脑功能连接强度（功能模块水平上结构-功能耦合）发生改变，其结构-功能耦合的畸变与精神分裂症的临床特征相关。

Clinical Study of DTI and Functional Magnetic Resonance Imaging to Explore the Strength of Brain Function Connection in Patients with Schizophrenia

ABSTRACT Objective: To investigate the clinical research of using DTI and functional magnetic resonance imaging to explore the strength of brain function connection in patients with schizophrenia. Methods: Patients with schizophrenia admitted to the Department of Psychiatry of our hospital from September 2017 to March 2018 were selected. Ninety-six patients were enrolled as the schizophrenia group, while 96 healthy volunteers were recruited as the control group at the same time. FMRIB software library was used to preprocess the structural data and construct the brain anatomy network for related analysis. Results: The functional connection strength of occipital lobe modules in the schizophrenia group was stronger than that of the control group(P<0.05), and the functional connection strength of cortical and fronto-parietal modules in the schizophrenia group was weaker than that of the control group(P<0.05). The default between the schizophrenia group and the control group There is no difference in the functional connection strength between the module and the central module(P>0.05). There was no difference in the structural connection strength of each module in the control group in the schizophrenia group(P>0.05). Compared with the control group, the schizophrenia group had an increased degree of structure-function connection between the default model module and the central module (P<0.05), and the schizophrenia group had a lower degree of structure-function connection between the occipital lobe module and the cortical module than the control group (P<0.05). There was no difference between the two groups in the degree of fast structure-function connection of the frontal parietal model(P>0.05). In the schizophrenia group, the structure-function connection score of the occipital lobe module was correlated with the duration of the disease (r=-0.528, P=0.006) and the overall symptoms of PANSS (r=-0.174, P=0.003). The structure-function connection score of PANSS was also significantly negatively correlated with the overall symptoms of PANSS (r=-0.405, P=0.034). It also revealed a significant negative correlation between the structure-function connection score of the cortical module and the duration of the disease (r=-0.336, P=0.029). Conclusion: The strength of brain function connection (structure-function coupling at the functional module level) of patients with schizophrenia has changed, and the aberration of structure-function coupling is related to the clinical features of schizophrenia.