半量睫状体光凝术对青光眼患者生活质量及血清Endothelin-1水平的影响

摘要 目的：探究半量睫状体光凝术对青光眼患者生活质量及血清内皮素（ET-1）水平的影响。方法：选择2018年4月至2021年4月于我院接受治疗的80例（80眼）青光眼患者为研究对象，将其按照接受术式的差异区分为研究组（n=40，接受半量睫状体光凝术治疗）与对照组（n=40，接受小梁切除术），观察记录两组患者术后前房反应及角膜水肿情况，分析两组患者术前术后眼压、视力以及血清ET-1水平变化，记录两组患者手术成功率和术后并发症发生情况并实施组间差异性比较。结果：（1）术后1 d和术后7 d两个时间点上，研究组与对照组患者的前房反应以及角膜内皮水肿情况组间比较无差异（P>0.05）；（2）研究组患者手术完全成功20例，相对成功19例，手术总成功率为97.50 %，对照组患者手术完全成功15例，相对成功22例，手术总成功率为87.50 %，两组患者手术成功率方面组间比较无差异（P>0.05）；（3）术后7 d、术后1个月及术后3个月时，研究组患者的眼压均明显低于对照组（P<0.05）；（4）术后1个月时两组患者的ET-1水平组间比较无差异（P>0.05），但研究组患者的生活质量高于对照组（P<0.05）；（5）两组患者在并发症发生率方面组间无差异（P>0.05）。结论：半量睫状体光凝术对青光眼具有较好的治疗效果，患者手术成功率相比小梁切除术更高，同时患者术后眼压降低明显，且手术安全性值得肯定。

Effect of Half Volume Ciliary Body Photocoagulation on Quality of Life and Serum Endothelin-1 Level in Patients with Glaucoma

ABSTRACT Objective: To explore the effect of half volume ciliary body photocoagulation on the quality of life and serum endothelin-1 (ET-1) level of glaucoma patients. Methods: 80 patients (80 eyes) with glaucoma treated in our hospital from April 2018 to April 2021 were selected as the research object, and they were divided into the research group (n=40, treated with half volume ciliary body photocoagulation) and the control group according to the difference of operation methods (n=40, trabeculectomy), observe and record the postoperative anterior chamber reaction and corneal edema of the two groups, analyze the changes of preoperative and postoperative intraocular pressure, visual acuity and serum ET-1 level of the two groups, record the operation success rate and postoperative complications of the two groups, and compare the differences between the two groups. Results: (1) There was no difference in anterior chamber reaction and corneal endothelial edema between the study group and the control group at 1 d and 7 d after operation (P>0.05); (2) In the study group, 20 cases were completely successful, 19 cases were relatively successful, and the total success rate was 97.50 %. In the control group, 15 cases were completely successful, 22 cases were relatively successful, and the total success rate was 87.50 %. There was no difference in the operation success rate between the two groups (P>0.05); (3) At 7 d, 1 month and 3 months after operation, the intraocular pressure in the study group was lower than that in the control group(P<0.05); (4) At 1 month after operation, there was no difference in the level of ET-1 between the two groups(P>0.05), but the quality of life in the study group was higher than that in the control group(P<0.05); (5) There was no difference in the incidence of complications between the two groups (P>0.05). Conclusion: Half volume ciliary body photocoagulation has a better therapeutic effect on glaucoma, the surgical success rate of patients is higher than trabeculectomy, the postoperative intraocular pressure of patients is significantly reduced, and the surgical safety is worthy of affirmation.