| 载阿霉素PLGA纳米微球的制备及性质研究 |
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| 引用本文： | 刘杰,徐伟华,金成,张福琴,窦科峰.载阿霉素PLGA纳米微球的制备及性质研究[J].现代生物医学进展,2010,10(24). |
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| 作者姓名： | 刘杰 徐伟华 金成 张福琴 窦科峰 |
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| 作者单位： | 第四军医大学西京医院肝胆胰脾外科,陕西,西安,710032 |
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| 摘 要： | 目的:制备新型癌症化疗制剂载阿霉素(Adriamycin)、聚乳酸-羟基乙酸共聚物(PLGA)纳米微球(ADM-PLGA-NP),研究其性质及体外释药特点。方法:以聚乳酸-羟基乙酸共聚物为包封材料,阿霉素为模型药物,采用复乳蒸发法制备ADM-PLGA-NP,扫描电镜观察微球形态,激光粒度分析仪检测粒径分布,紫外分光光度法计算载药率及包封率,体外药物释放实验考察微球对ADM的缓释作用。结果:ADM-PLGA-NP外观呈球形,平均粒径约(237±12.7)nm,载药量及包封率分别为(6.42±1.67)%和(53.82±8.34)%,药物在体外缓慢释放,5 d累积释放量达85%。结论:通过复乳蒸发法制备的ADM-PLGA-NP性质稳定,具有药物缓释性,有望成为一种新型的药物化疗载体。
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| 关 键 词： | 阿霉素 乳酸-羟基乙酸共聚物 纳米微球 缓释 |
Study on Preparation of Adriamycin-loaded PLGA Nanoparticles in Vitro |
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| LIU Jie,XU Wei-hua,JIN Cheng,ZHANG Fu-qin,DOU Ke-feng.Study on Preparation of Adriamycin-loaded PLGA Nanoparticles in Vitro[J].Progress in Modern Biomedicine,2010,10(24). |
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| Authors: | LIU Jie XU Wei-hua JIN Cheng ZHANG Fu-qin DOU Ke-feng |
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| Institution: | LIU Jie,XU Wei-hua,JIN Cheng,ZHANG Fu-qin,DOU Ke-feng(Department of Hepato-biliary & Pancreato-Splenic Surgery,Xijing Hospital,Fourth Military Medical University,Xi'an,710032,China) |
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| Abstract: | Objective: To prepare adriamycin-loaded poly(D,L-lactide-co-glycolide) nanoparticles(ADM-PLGA-NP) and to inves-tigate the characteristics and drug-release properties of ADM-PLGA-NPs in vitro.Methods: ADM-PLGA-NPs were prepared by w/o/w emulsification-solvent evaporation method,in which PLGA was as embedding materials,adriamycin was as embedded drug.The mor-phology and diameters were detected by scanning electron microscopy(SEM) and dynamic light scatter(DLS),respectively.The encap-sulating efficiency of ADM... |
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| Keywords: | Adriamycin Poly(D L-lactide-co-glycolide) Nanospheres Sustained release |
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