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小剂量米非司酮和左炔诺孕酮用于紧急避孕的临床研究
引用本文:步桂英,??,杨铭越,??,曹雪莲.小剂量米非司酮和左炔诺孕酮用于紧急避孕的临床研究[J].现代生物医学进展,2006,6(2):53-54.
作者姓名:步桂英  ??  杨铭越  ??  曹雪莲
作者单位:1. 黑龙江省齐齐哈尔市富拉尔基区人民医院妇产科,161041
2. 黑龙江省齐齐哈尔一重医院妇产科,161041
摘    要:目的:以左炔诺孕酮为参比制剂,探讨10mg米非司酮用于紧急避孕的临床效果。副反应及可接受性。方法:采用随机对照性的试验方法,征集100例单次无保护性交72小时内来院就诊的要求紧急避孕的妇女,随机分配到观察组(n=50)和对照组(n=50),观察组单次口服10mg米非司酮,对照组口服左炔诺孕酮0.75mg,12小时后再服左炔诺孕酮0.75mg,服药后嘱两组对象按时随访直至月经复潮。并观察其避孕效果,副反应,对月经的影响及药物的可接受性。结果:采用Dixon方法计算。两组对象各有1例妊娠,观察组避孕效果达81.19%,对照组为81.06%,统计学上无明显差并,两组副反应轻,无任何不良反应发生。结论:小剂量米非司酮用于紧急避孕与左炔诺孕酮是同样有效的。

关 键 词:米非司酮  左炔诺孕酮  紧急避孕
收稿时间:2005-12-19
修稿时间:2006-01-23

Clinical study on Administration of Low Dose of Mifepristone and Levonorgestrel in Urgent Postcoital Contraception
BU Gui- ying,YANG Ming - yue,CAO Xue- lian.Clinical study on Administration of Low Dose of Mifepristone and Levonorgestrel in Urgent Postcoital Contraception[J].Progress in Modern Biomedicine,2006,6(2):53-54.
Authors:BU Gui- ying  YANG Ming - yue  CAO Xue- lian
Abstract:Objective: To investigate the clinical effects of administration of low dose of Mifepristone(10mg) in urgent contraception,taking Levonorgestrel as reference preparation.Methods: 100 women,who had once had unprotecting coition and asked for urgent contraception within 72 hours after sexual intercourse,were randomly divided into observation group(n=50) and control group(n=50).The observation group was given only mifepristone(10mg,orally);while the control group was firstly given levonorgestrel(0.75mg,orally) and then levonorgestrel(0.75mg,orally) again in 12 hours.After administration,the women in the two groups were told to be followed up statedly until the next menstruation appears.Meanwhile,birth control effect,side effects,the influence of the medicines on menstruation and medicinal acceptability were observed. Results: According to Dixon method,there was 1 pregnant woman in each group,respectively.The contraception rate of observation group was 81.19%,and that of control group 81.06%.Statistically,there was no significant difference between the two groups,with slight side effects.Conclusion: Low dose of Mifepristone is suitable for urgent contraception,which has the same effect as Levonorgestrel.
Keywords:Mifepristone  Levonorgestrel  Urgent contraception
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