| 聚乙二醇丙烯酸酯的合成与表征 |
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| 引用本文： | 刘亚兰??,雷忠利??,赵俊超.聚乙二醇丙烯酸酯的合成与表征[J].现代生物医学进展,2006,6(5):41-43. |
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| 作者姓名： | 刘亚兰?? 雷忠利?? 赵俊超 |
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| 作者单位： | 陕西师范大学化学与材料科学学院,陕西,西安,710062 |
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| 摘 要： | 以聚乙二醇-400（PEG400）与丙烯酸直接缩合反应，在不加有毒带水剂的条件下合成了丙烯酸聚乙二醇酯（PEGA）。通过正交实验确定酯化反应的最佳条件：丙烯酸／PEG400的摩尔比为2．0：1．0，反应温度是110℃，阻聚剂对苯二酚为0．4％（以醇酸总质量计），反应时间为6小时，催化剂对甲苯磺酸为0．8％（以醇酸总质量计），产率为76．7％。产品结构经IR和1HNMR表征，证明是所需的产物。
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| 关 键 词： | 聚乙二醇丙烯酸酯 正交实验 合成 表征 |
| 收稿时间： | 2006-04-14 |
| 修稿时间： | 2006-04-28 |
Synthesis and Characterization of Polyethylene Glycol Acrylate |
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| LIU Ya- lan,LEI Zhong- li,ZHAO Jun- chao.Synthesis and Characterization of Polyethylene Glycol Acrylate[J].Progress in Modern Biomedicine,2006,6(5):41-43. |
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| Authors: | LIU Ya- lan LEI Zhong- li ZHAO Jun- chao |
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| Abstract: | Polyethylene glycol acrylate ( PEGA) was synthesized by condensation of PEG( 400) and acrylic acid without water- car??
rying reagent. The optimal condition of esterification was studied by the orthogonal design that the molar rate of acrylic acid to PEG was 2. 0: 1. 0,
the reaction temperature was 110?? , the reaction time is 6h, the amount of hydroquinone and p- methy benzene sulfonic acid was 0. 4% and 0.
8%, respectively ( according to the mass of PEG and acrylic acid) . The structure of the PEGA was characterized by FTIR, and 1HNMR. . The
ester yield reached 81% according to 1HNMR. |
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| Keywords: | Polyethylene glycol acrylate Orthogonal design Synthesis Characterization |
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