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Lack of association of EGR2 variants with bipolar disorder in Japanese population |
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| Authors: | Shabeesh Balan Kazuo Yamada Yoshimi Iwayama Tomoko Toyota Tetsuo Ohnishi Motoko Maekawa Manabu Toyoshima Yasuhide Iwata Katsuaki Suzuki Mitsuru Kikuchi Hiroshi Ujike Toshiya Inada Hiroshi Kunugi Norio Ozaki Nakao Iwata Shinichiro Nanko Tadafumi Kato Takeo Yoshikawa |
| Institution: | 1. Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351-0198, Japan;2. Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan;3. Department of Psychiatry and Neurobiology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan;4. Ujike Nishiguchi Clinic, Okayama 700-0024, Japan;5. Seiwa Hospital, Institute of Neuropsychiatry, Tokyo 162-0851, Japan;6. Department of Mental Disorder Research, National Institute of Neuroscience, Tokyo 187-8502, Japan;g Department of Psychiatry, Graduate School of Medicine, Nagoya University, Aichi 466-8850, Japan;h Department of Psychiatry, Fujita Health University School of Medicine, Aichi 470-1192, Japan;i Department of Psychiatry and Genome Research Center, Teikyo University of Medicine, Tokyo 173-8605, Japan;j Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351-0198, Japan |
| Abstract: | The early growth response gene 2 (EGR2) has been recently reported to be associated with bipolar disorder in the Korean population. However replication studies in independent cohorts of same and different ethnicities are essential for establishing the credibility of a genotype–phenotype association. With this notion, in the present study we have performed a replication study of the reported association of SNPs in EGR2 in a case–control study comprising of 867 unrelated Japanese bipolar disorder patients and 895 age-, sex- and ethnicity-matched controls. Results showed no significant differences in allele and genotype frequencies of EGR2 SNPs between bipolar disorder patients and controls and also in a sex-stratified genetic analysis. The haplotype and meta-analyses also showed no significant association with bipolar disorder. In conclusion, this is the first replication study of the previously reported association of EGR2 with bipolar disorder in a larger sample set and the results showed that the EGR2 gene is unlikely to contribute to the susceptibility of bipolar disorder in a Japanese cohort. |
| Keywords: | EGR2 early growth response gene 2 COSMO Collaborative Study of Mood Disorders consortium SNP single nucleotide polymorphism LD linkage disequilibrium DSM-IV Diagnostic and Statistical Manual of Mental Disorders-IV |
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