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Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes |
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| Authors: | Marijana Popović Hadžija Marina Korolija Nikolina Jemin Iva Pavković Pajica Pavković Edita Pape Medvidović Mirko Hadžija |
| Institution: | 1. Ru?er Boškovi? Institute, Division of Molecular Medicine, Zagreb, Croatia;2. University Hospital Center, Zagreb, Croatia;3. Vuk Vrhovac University Clinic, Zagreb, Croatia |
| Abstract: | Genetic variants of IL-18 and IL-12B may be important in immunoregulatory abnormalities, observed in the patients with Type 1 diabetes mellitus (T1DM), that contribute to individual differences in response to a treatment. Therefore, we examined the significance of IL-18-137G/C, IL-18-607C/A, and IL-12B A/C polymorphisms in Croatians (187 patients, 236 controls), not only as factors that contribute to susceptibility to T1DM, but also as determinants of the clinical presentation of disease. |
| Keywords: | EDTA ethylenediaminetetraacetic acid CI confidence intervals HbA1c glycated hemoglobin IFN-γ interferon-gamma IL-1 interleukin-1 IL-12 interleukin-12 IL-18 interleukin-18 HWE Hardy&ndash Weinberg equilibrium OGTT oral glucose tolerance test OR odds ratio PCR polymerase chain reaction RFLP restriction fragment length polymorphism SNP single nucleotide polymorphism T1DM type 1 diabetes mellitus TNF-α tumor necrosis factor-alpha WHO World Health Organization |
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