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Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome |
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| Authors: | Uyen DP Lam Elisabeth Lerchbaum Natascha Schweighofer Olivia Trummer Katharina Eberhard Bernd Genser Thomas R Pieber Barbara Obermayer-Pietsch |
| Institution: | 1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A-8036 Graz, Austria;2. Center for Medical Research, Medical University of Graz, Stiftingtalstraße 24, A-8010 Graz, Austria;3. Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Ludolf-Krehl-Straße 7-11, D-68167 Mannheim, Germany;4. Instituto de Saúde Coletiva, Federal University of Bahia, Rua Basílio da Gama, Campus Universitário Canela, Cep: 40.110-040 Salvador, BA, Brazil |
| Abstract: | Polycystic ovary syndrome (PCOS) shows not only hyperandrogenemia, hirsutism and fertility problems, but also metabolic disturbances including obesity, cardiovascular events and type-2 diabetes. Accumulating evidence suggests some degree of inflammation associated with prominent aspects of PCOS. We aimed to investigate the association of genetic variants 3′UTR rs17468190 (G/T) of the inflammation-associated gene MEP1A (GenBank ID: NM_005588.2) with metabolic disturbances in PCOS and healthy control women. |
| Keywords: | ANOVA analysis of variance ASRM American Society for Reproductive Medicine BMI body mass index DHEAS dehydroepiandrosterone sulfate DNA deoxyribonucleic acid EDTA ethylenediaminetetraacetate ESHRE European Society of Human Reproduction and Embryology FAI free androgen index fT free testosterone GNRH1 gonadotropin-realeasing hormone HDL high density lipoprotein HOMA-IR homeostatic model assessment-insulin resistance IR insulin resistance LDL low density lipoprotein NCBI National Center for Biotechnology Information NICHD National Institute of Child Health and Human Development PASW Predictive Analytics Software PCOS polycystic ovary syndrome PTH parathyroid hormone QChol/HDL quotient total cholesterol to HDL SHBG sex hormone-binding globulin SI International System of Units SNP single nucleotide polymorphism TG triglycerides TT total testosterone 25(OH)D 25-hydroxyvitamin D 3&prime UTR 3&prime untranslated regions WHR waist-to-hip ratio |
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