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Sequence analysis of the 5′-flanking region of the gene encoding human N-acetylglucosaminyltransferase III |
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| Authors: | Yeon-Jeong Kim Jong-Hoon Park Koung-Sook Kim Ji-Eun Chang Jeong Heon Ko Myung-Hee Kim Dong-Hyo Chung Tae-Wha Chung In-Seong Choe Young-Choon Lee Cheorl-Ho Kim |
| Institution: | a Laboratory of Molecular and Cellular Biology, Korea Research Institute of Bioscience and Biotechnology (KRIBB), KIST, Taejon 305-600., South Korea b Department of Food Science and Technology. Chungang University, Ansong, South Korea. Tel. (82-2) 233-4521 c Genetic Resources Center, KRIBB, KIST, Taejon 305-600, South Korea. Tel. (82-42) 860-4642 d Glycobiology Program, KRIBB, KIST, Taejon, 305-600, South Korea. Tel. (82-42) 860-4260 |
| Abstract: | We have isolated and characterized the immediate (1651 bp) 5′-flanking region of the gene (GnT-III) encoding N-acetylglucosaminyltransferase III (GnT-III) from a human placental genomic library. Analysis of promoter elements shows a similarity to the 5′-flanking region of murine 1,4-galactosyltransferase. The sequence lacks obvious TATA elements and CCAAT boxes; however, putative regulatory sites, including 2 potential cAMP-response regulatory elements (CRE), 11 insulin-response element consensus sequences (IRE), 7 potential AP-2-binding sites, 2 SP1 consensus sequences (GC boxes) and 2 sequences similar to the half-palindromic glucocorticoid-responsive element (GRE), are present. |
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