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Circadian rest-activity rhythm in chronic obstructive pulmonary disease |
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| Authors: | Deuzilane Muniz Nunes Bruno S B Gonçalves Carina Aparecida Tardelli Peixoto Veralice Meireles Sales De Bruin Fernando Mazzilli Louzada |
| Institution: | 1. Department of Pharmacy, Universidade Federal do Vale do S?o Francisco, Petrolina, Pernambuco, Brazil;2. School of Arts, Sciences and Humanities, Universidade de S?o Paulo, S?o Paulo, Brazil;3. Graduated in Physiology, Universidade do Contestado, Porto Uni?o, Santa Catarina, Brazil;4. Laboratory of Sleep and Biological Rhythms, School of Medicine, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil;5. Department of Physiology, Universidade Federal do Paraná, Curitiba, Paraná, Brazil |
| Abstract: | To characterize circadian rest-activity rhythm in COPD, 26 cases (66.9 ± 8.5y) and 15 controls (63.0 ± 10.7y) were assessed by actimetry. Rhythm fragmentation was measured by intradaily variability (IV), while synchronization to the 24-h light-dark cycle was measured by interdaily stability (IS). The average activity during the least active 5-h period (L5) and the average activity during the most active 10-h period (M10) were used to calculate the relative amplitude mean RAm = (M10-L5)/(M10+L5)]. COPD patients presented higher IVm (0.242 ± 0.097 vs 0.182 ± 0.063) and L5 (36.849 ± 18.239 vs 19.888 ± 12.268) and lower RAm (0.696 ± 0.134 vs 0.833 ± 0.093) than controls. Future studies on the effects of chronotherapy measures in COPD are warranted. |
| Keywords: | pulmonary disease chronic obstructive circadian rhythm actigraphy physical activity sleep |