NMR studies of prebiotic polypeptides |
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Authors: | Salvatore Andini Ettore Benedetti Luciano Ferrara Livio Paolillo Piero Andrea Temussi |
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Institution: | 1. Instituto Chimico, Università di Napoli, 80134, Naples, Italy
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Abstract: | Several polypeptides prepared by means of pyrocondensation have been the subject of structural investigations. Attention has been focused on the constitutional characterization of homo-and co-polymers containing Asp and Glu residues, whose role is essential for the formation of the so-called proteinoids. Contrary to the literature data based on chemical degradation, nmr studies show conclusively that in thermal poly-aspartic acid only β-peptide linkages are present. This result casts serious doubt on the role thermal condensation might have played in prebiotic polypeptide syntheses. |
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