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Microbiota transplantation: concept,methodology and strategy for its modernization
Authors:Faming Zhang  Bota Cui  Xingxiang He  Yuqiang Nie  Kaichun Wu  Daiming Fan  FMT-standardization Study Group
Abstract:Fecal microbiota transplantation (FMT) has become a research focus of biomedicine and clinical medicine in recent years. The clinical response from FMT for different diseases provided evidence for microbiota-host interactions associated with various disorders, including Clostridium difficile infection, inflammatory bowel disease, diabetes mellitus, cancer, liver cirrhosis, gutbrain disease and others. To discuss the experiences of using microbes to treat human diseases from ancient China to current era should be important in moving standardized FMT forward and achieving a better future. Here, we review the changing concept of microbiota transplantation from FMT to selective microbiota transplantation, methodology development of FMT and stepup FMT strategy based on literature and state experts’ perspectives.
Keywords:selective microbiota transplantation  microbiome  bacteria  Clostridium difficile  inflammatory bowel disease  step-up fecal microbiota transplantation  perspectives  
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